PMID: 25764607Mar 15, 2015Paper

A reduction of asymmetric dimethylarginine in renal transplant recipients receiving sirolimus-based regimen

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
Nuttaphat NamjudSupeecha Wittayalertpanya

Abstract

Sirolimus may be of benefit in terms ofa reduction of cardiovascular disease in renal transplant recipients. The aim of the present study was to investigate cardiovascular risk markers in renal transplant recipients receiving calcineurin inhibitors (CNI-based regimen), as compared to those receiving sirolimus (SRL-based regimen). 42 patients were recruited (21 patients for each regimen). Plasma concentrations of cardiovascular risk markers, including asymmetric dimethylarginine (ADMA), nitric oxide (NO), homocysteine (Hcy), and total antioxidant status (TAOS) were measured. Plasma ADMA concentrations were lower in patients with SRL-based regimen, as compared to those with CNI-based regimen (0.52 ± 0.02 and 0.60 ± 0.02 μmol/L, p = 0.027). There were no statistically significant differences seen in NO, Hcy, and TAOS between the two treatments. As compared to CNI-based regimen, cardiovascular risk marker (ADMA) levels are lower in patients with SRL-based regimen.

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