A reference frame for blood volume in children and adolescents

BMC Pediatrics
Ann RaesJohan Vande Walle

Abstract

Our primary purpose was to determine the normal range and variability of blood volume (BV) in healthy children, in order to provide reference values during childhood and adolescence. Our secondary aim was to correlate these vascular volumes to body size parameters and pubertal stages, in order to determine the best normalisation parameter. Plasma volume (PV) and red cell volume (RCV) were measured and F-cell ratio was calculated in 77 children with idiopathic nephrotic syndrome in drug-free remission (mean age, 9.8 +/- 4.6 y). BV was calculated as the sum of PV and RCV. Due to the dependence of these values on age, size and sex, all data were normalised for body size parameters. BV normalised for lean body mass (LBM) did not differ significantly by sex (p < 0.376) or pubertal stage (p < 0.180), in contrast to normalisation for the other anthropometric parameters. There was no significant difference between reference values for children and adults. LBM was the anthropometric index most closely correlated to vascular fluid volumes, independent of age, gender and pubertal stage.

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Citations

Nov 23, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ann RaesJohan Vande Walle
Apr 22, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M SulingUNKNOWN IDEFICS Consortium
Aug 10, 2007·Proceedings. Biological Sciences·David Dingli, Jorge M Pacheco
Nov 30, 2012·Malaria Journal·Erica M W BilligF Ellis McKenzie
Mar 8, 2012·Malaria Journal·Erica M W BilligF Ellis McKenzie
May 27, 2011·Pharmaceutical Development and Technology·Eleri WallaceCharles M Heard
Oct 14, 2009·British Journal of Haematology·Georg HempelJoachim Boos
Mar 30, 2017·European Journal of Drug Metabolism and Pharmacokinetics·Gudrun WürthweinJoachim Boos
Apr 24, 2007·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Steven C CurryDale S Bikin
Nov 6, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Chia-Ying LiuJoão A C Lima
May 12, 2018·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·David M SaylorRichard A Malinauskas
Dec 30, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Samantha H WitzelGuido Filler
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Feb 18, 2021·European Journal of Drug Metabolism and Pharmacokinetics·Gudrun WürthweinUNKNOWN AIEOP-BFM ALL 2009 Asparaginase Working Party
May 5, 2021·Experimental Physiology·Erica Mancera-SotoEdgar Cristancho-Mejía
Aug 27, 2021·Clinical Pharmacology in Drug Development·Yutaka FukayaHiroshi Kawamoto
Aug 29, 2021·Pharmaceutics·Christopher F van der WalleZein Azhari

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