Dec 23, 2015

A reference panel of 64,976 haplotypes for genotype imputation

BioRxiv : the Preprint Server for Biology
Shane McCarthyJonathan Marchini

Abstract

We describe a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole genome sequence data from 20 studies of predominantly European ancestry. Using this resource leads to accurate genotype imputation at minor allele frequencies as low as 0.1%, a large increase in the number of SNPs tested in association studies and can help to discover and refine causal loci. We describe remote server resources that allow researchers to carry out imputation and phasing consistently and efficiently.

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Mentioned in this Paper

Study
Genome
Research Personnel
Alleles
Single Nucleotide Polymorphism
Genotype Determination
BAT Loci
Location - Remote

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