A regenerative peripheral nerve interface allows real-time control of an artificial hand in upper limb amputees.

Science Translational Medicine
Philip P VuPaul S Cederna

Abstract

Peripheral nerves provide a promising source of motor control signals for neuroprosthetic devices. Unfortunately, the clinical utility of current peripheral nerve interfaces is limited by signal amplitude and stability. Here, we showed that the regenerative peripheral nerve interface (RPNI) serves as a biologically stable bioamplifier of efferent motor action potentials with long-term stability in upper limb amputees. Ultrasound assessments of RPNIs revealed prominent contractions during phantom finger flexion, confirming functional reinnervation of the RPNIs in two patients. The RPNIs in two additional patients produced electromyography signals with large signal-to-noise ratios. Using these RPNI signals, subjects successfully controlled a hand prosthesis in real-time up to 300 days without control algorithm recalibration. RPNIs show potential in enhancing prosthesis control for people with upper limb loss.

References

Jan 1, 1993·IEEE Transactions on Bio-medical Engineering·B HudginsR N Scott
Jul 1, 1997·Journal of Applied Physiology·M SahinI A Dreshaj
May 25, 1999·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·J J StruijkT Sinkjaer
Oct 5, 2005·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Abidemi Bolu Ajiboye, Richard F ff Weir
Oct 14, 2005·Journal of the Peripheral Nervous System : JPNS·Xavier NavarroPaolo Dario
Aug 31, 2007·Journal of Neurophysiology·Ping ZhouTodd A Kuiken
Feb 13, 2009·JAMA : the Journal of the American Medical Association·Todd A KuikenKevin B Englehart
May 29, 2009·IEEE Transactions on Bio-medical Engineering·Francesco V G TenoreNitish V Thakor
Jan 15, 2010·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Guanglin LiTodd A Kuiken
Feb 5, 2011·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Christian CiprianiFredrik Sebelius
Aug 24, 2011·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Kenneth HorchDouglas T Hutchinson
Dec 20, 2011·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Silvia Muceli, Dario Farina
Sep 3, 2013·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Ning JiangDario Farina
Nov 28, 2013·Plastic and Reconstructive Surgery·Theodore A KungPaul S Cederna
Feb 7, 2014·Science Translational Medicine·Stanisa RaspopovicSilvestro Micera
Feb 25, 2014·Archives of Physical Medicine and Rehabilitation·William D MembergRobert F Kirsch
Feb 25, 2014·Clinical Orthopaedics and Related Research·Jason M SouzaGregory A Dumanian
May 23, 2014·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Ali AmeriPhilip A Parker
May 29, 2014·Plastic and Reconstructive Surgery·Theodore A KungMelanie G Urbanchek
Oct 10, 2014·Science Translational Medicine·Daniel W TanDustin J Tyler
Feb 17, 2015·Seminars in Plastic Surgery·Jennifer E CheesboroughGregory A Dumanian
Nov 26, 2015·Journal of Neural Engineering·Lauren H SmithLevi J Hargrove
Feb 10, 2016·Journal of Neural Engineering·Daniel C UrsuR Brent Gillespie
Jun 14, 2016·BioMed Research International·Melanie G UrbanchekPaul S Cederna
Mar 16, 2017·Plastic and Reconstructive Surgery. Global Open·Shoshana L WooPaul S Cederna
Feb 13, 2018·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Philip P VuCynthia A Chestek
May 31, 2018·JAMA Surgery·Carrie A KubiakPaul S Cederna
Dec 14, 2018·Journal of Neural Engineering·Michael D TwardowskiJoshua C Kline
Aug 29, 2019·Plastic and Reconstructive Surgery·Carrie A KubiakTheodore A Kung

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Citations

May 16, 2020·Muscle & Nerve·Philip P VuPaul S Cederna
Jun 4, 2020·Current Reviews in Musculoskeletal Medicine·Taylor J BatesSarah N Pierrie
Sep 23, 2020·Nature Biomedical Engineering·Dzmitry AfanasenkauPavel Musienko
Nov 25, 2020·Der Orthopäde·Clemens GstoettnerOskar C Aszmann
Feb 24, 2021·Bioelectronic Medicine·Alexis L Lowe, Nitish V Thakor
Feb 27, 2021·Journal of Neuroengineering and Rehabilitation·Michael D PaskettGregory A Clark
Mar 20, 2021·Journal of Neuroengineering and Rehabilitation·Platon LukyanenkoMatthew R Williams
Apr 4, 2021·Cancer Discovery·Padmanee SharmaJames P Allison
Dec 9, 2020·Muscle & Nerve·Yaxi HuMelanie G Urbanchek
Jun 2, 2021·Nature Biomedical Engineering·Dario FarinaOskar C Aszmann
Jun 23, 2021·Artificial Organs·Mijail D Serruya, Robert H Rosenwasser
Jul 13, 2021·Frontiers in Neuroscience·Diu K LuuZhi Yang
Jun 15, 2021·Seminars in Plastic Surgery·Rami P DibbsJohn C Koshy
Jul 14, 2021·Hand Clinics·Alex K Vaskov, Cynthia A Chestek
Aug 10, 2021·Frontiers in Neurorobotics·Alison M KarczewskiSamuel O Poore
Oct 2, 2021·ELife·Matthias LuftKonstantin Davide Bergmeister

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