PMID: 9554249Apr 29, 1998Paper

A regimen of oral contraceptives restricted to the periovulatory period may permit folliculogenesis but inhibit ovulation

Contraception
G S Letterie

Abstract

Increased safety of oral contraceptives (OC) has resulted from a reduction in the estrogen and progestin content per tablet. A reduction in the number of hormonally active pills and their placement at critical points within the cycle may provide a novel regimen for further reducing the hormonal content of OC per cycle and their attendant side effects without compromising efficacy. The objective of this study was to determine the effectiveness of two OC regimens that incorporate a delayed start and limited midcycle use of the combination of ethinyl estradiol and norethindrone, and limited use of norethindrone only during the second half of the cycle. Main outcome measures were defined as ovulation, serum concentrations of estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH), progesterone (P), follicular diameters, and endometrial thickness. Volunteers were issued blister packs containing 28 pills and randomized to one of two groups. Group 1 used a combination of 50 micrograms ethinyl estradiol and 1 mg norethindrone per tablet day 6-10, and 0.70 mg norethindrone only day 11-19. Placebo tablets were used on days 1-5 and day 20-28. Group 2 used a combination of 50 micrograms ethinyl estradiol and 1 mg noret...Continue Reading

References

Feb 1, 1992·International Journal of Epidemiology·M ThorogoodM Vessey
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·O PeraltaH Croxatto
Feb 1, 1994·Biology of Reproduction·J E Fortune

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Citations

Oct 29, 2013·Environmental Toxicology and Pharmacology·W Baylor SteeleThomas W La Point
Jan 18, 2006·Contraception·Kathryn M CurtisHerbert B Peterson
Jun 1, 2005·The Journal of Family Planning and Reproductive Health Care·UNKNOWN Faculty of Family Planning and Reproductive Health Care Clinical Effectiveness Unit

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