Abstract
Overwhelming post-splenectomy infection (OPSI) is a serious complication of asplenia. Clinical guidelines recommend numerous measures to reduce the risk of OPSI, but awareness and adherence to preventative measures are generally poor. We aimed to determine whether a registry for asplenic/hyposplenic patients was associated with a reduction in the incidence of infection with encapsulated bacteria. We performed a retrospective cohort study of asplenic/hyposplenic patients in the state of Victoria, Australia, who registered with Spleen Australia from 2003 through 2014. Spleen Australia provides education, clinical guidance, and annual vaccination reminders to registrants and their healthcare providers. We compared the incidence of infection with Streptococcus pneumoniae, Haemophilus influenzae type B (Hib), and Neisseria meningitidis before and after registration. Registry data were linked with Victorian notifiable disease data on invasive pneumococcal disease (IPD), invasive meningococcal disease (IMD), and Hib between 2000 and 2014. Twenty-seven cases of IPD and 1 of IMD occurred among 3221 registrants. No cases of Hib were reported. The rate of IPD/IMD was 150 per 100000 patient-years prior to registration and 36 per 100000 pat...Continue Reading
References
Nov 4, 2000·The Medical Journal of Australia·G G HoggR A Lester
Mar 17, 2001·Journal of Clinical Pathology·D J Waghorn
Jan 28, 2004·The Hematology Journal : the Official Journal of the European Haematology Association·Mohsen Saleh El-Alfy, Manal Hamdy El-Sayed
Feb 8, 2005·Irish Journal of Medical Science·J O'DonnellD J Bouchier-Hayes
Mar 11, 2005·Expert Review of Vaccines·David V Shatz
Mar 16, 2007·Epidemiology and Infection·H J ClothierS B Lambert
Feb 21, 2008·Internal Medicine Journal·D SpelmanUNKNOWN Australasian Society for Infectious Diseases
Oct 14, 2008·Vaccine·A Meerveld-EgginkD H Biesma
Oct 31, 2008·ANZ Journal of Surgery·Anna WilkesStephen Smith
Jan 23, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A J J LammersP Speelman
Apr 9, 2011·Lancet·Antonio Di SabatinoGino Roberto Corazza
Oct 18, 2011·Journal of Infection and Public Health·Hélène Coignard-BiehlerOlivier Lortholary
May 25, 2012·The Medical Journal of Australia·Claire DendleIan Woolley
Feb 4, 2014·The Medical Journal of Australia·Robert I MenziesPeter B McIntyre
May 20, 2014·The Medical Journal of Australia·Julie WangKarin Leder
Jul 15, 2015·The Journal of Surgical Research·Gerald P KealeyGraeme Pitcher
Apr 21, 2016·Epidemiology and Infection·G L LawrenceP B McINTYRE
Dec 8, 2016·Internal Medicine Journal·Kudzai KanhutuDenis Spelman
Citations
Feb 23, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Antonio Di SabatinoGino Roberto Corazza
Jul 19, 2018·Human Vaccines & Immunotherapeutics·Sarah LuuIan J Woolley
Sep 22, 2018·Australian and New Zealand Journal of Public Health·Sarah LuuLisa Gold
Dec 12, 2018·Expert Review of Vaccines·Reinaldo AcevedoBingqing Zhu
Jan 16, 2020·BMC Infectious Diseases·Marianne BayrhuberSiegbert Rieg
Jun 20, 2019·Internal and Emergency Medicine·Paolo GiuffridaAntonio Di Sabatino
Mar 12, 2020·Open Forum Infectious Diseases·Siegbert RiegChristian Theilacker
Aug 8, 2020·BMJ Open Quality·Natalya Elizabeth O'NeillMichelle Sholzberg
May 1, 2020·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Hans-Jürgen LawsFred Zepp
Aug 14, 2020·BMC Family Practice·Charlotte QuéffélecEtienne Rivière
Feb 28, 2020·Critical Care : the Official Journal of the Critical Care Forum·Damien ContouUNKNOWN HOPEFUL Study Group
Nov 25, 2020·The American Surgeon·Robert A GonzalezRoxie M Albrecht
Jan 27, 2021·Lupus·Tina KoAlberta Hoi
Nov 2, 2019·Infectious Disease Clinics of North America·Deirdre Fitzgerald, Grant W Waterer