PMID: 216899Oct 25, 1978

A regulatory system controlling the production of cytochrome aa3 in Neurospora crassa

Molecular & General Genetics : MGG
H Bertrand, R A Collins

Abstract

The mitochondria of the cyt-2-1, cya-3-16, cya-4-23 and 299-1 nuclear mutants and the [mi-3] and [exn-5] cytoplasmic mutants of Neurospora crassa are deficient in cytochrome aa3, while the cyb-1-1 and cyb-2-1 mutants have mitochondrial b-cytochrome deficiencies. However, the mitochondria from cyb-1-1 cyt-2-1, cyb-1-1 [mi-3] and cyb-2-1 [mi-3] double mutants contain 30% to 50% of the amount of cytochrome aa3 that is present in mitochondria from wild-type; i.e. cyb-1-1 and cyb-2-2 act as suppressors of the cytochrome aa3 deficiency phenotypes that are associated with cyt-2-1 and [mi-3] mutations. The production of cytochrome aa3 can be induced in cyt-2-1 and [mi-3] by growing cells in medium containing antimycin A, an inhibitor of electron transport in the cytochrome bc1 segment of the mitochondrial electrontransport chain. Moreover, the growth of the [mi-3] mutant is strongly stimulated by low concentrations of antimycin A. The induction of cytochrome aa3 by antimycin treatments does not occur in [exn-5], cya-4-23 and 299-1 cells; but does take place in cya-3-16 cells. Although some of the seven constituent polypeptides of cytochrome aa3 are present in mitochondria of [mi-3], the holoenzyme complex is not formed in the mutant. I...Continue Reading

References

Oct 3, 1977·European Journal of Biochemistry·H Bertrand, S Werner
Jun 24, 1977·Molecular & General Genetics : MGG·H BertrandC A Zagozeski
Sep 1, 1976·Canadian Journal of Genetics and Cytology. Journal Canadien De Génétique Et De Cytologie·H BertrandJ C Harrigan
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·Z Barath, H Küntzel
Jan 1, 1972·Molecular & General Genetics : MGG·H Bertrand, T H Pittenger
Nov 1, 1971·Archives of Biochemistry and Biophysics·D S Beattie
Nov 7, 1972·European Journal of Biochemistry·W SebaldG Jackl
Nov 7, 1972·European Journal of Biochemistry·A J SchwabH Weiss
Jan 23, 1974·Biochemical and Biophysical Research Communications·E G GollubD B Sprinson
Mar 1, 1968·Journal of General Microbiology·H BertrandT H Pittenger
Sep 27, 1967·Biochemical and Biophysical Research Communications·H Wohlrab, E E Jacobs
Oct 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·D J LUCK, E REICH
Jul 1, 1953·Proceedings of the National Academy of Sciences of the United States of America·M B MitchellA Tissieres

Related Concepts

Antimycin A1
Cytochrome c Oxidase Subunit VIa
Cytochromes
Enzyme Induction
Mitochondria
Neurospora
Neurospora crassa

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