PMID: 6540613Jul 23, 1984Paper

A reinvestigation of the analgesic effects induced by stimulation of the periaqueductal gray matter in the rat. I. The production of behavioral side effects together with analgesia

Brain Research
V FardinJ M Besson

Abstract

It has been shown that stimulation-produced-analgesia (SPA) in the cat elicited from the periaqueductal gray matter (PAG) is obtained from sites located in the ventral part, particularly the dorsal raphé nucleus (DRN). These data contrast with the numerous studies performed in the rat in which efficient sites seem widely distributed throughout the PAG. These discrepancies led us to reinvestigate SPA from PAG and adjacent structures in the rat. Central stimulation was delivered through bipolar concentric electrodes (one for each animal). Analgesia was evaluated (before and during central stimulation) by measuring the modification in the vocalization threshold induced by electrical tail shocks or by considering the reaction of the animal to pinch. In contrast with the majority of previous studies, these experiments were performed on the totally freely-moving rat. The most striking result was that, in order to obtain analgesia from all regions of the PAG, it was necessary to apply intensities of central stimulation which also triggered other strong behavioral reactions. With intensities of PAG stimulation which did not induce such side effects, very few effective analgesic sites were found (21/129 sites of which 14/83 were strictl...Continue Reading

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Citations

Jan 1, 1989·Neir̆ofiziologiia = Neurophysiology·A P GokinIu P Limanskiĭ
Jun 21, 1988·Brain Research·F P Zemlan, M M Behbehani
Mar 1, 1991·Physiology & Behavior·C G MarkgrafN Schneiderman
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May 5, 2001·Physiology & Behavior·M DiotteE Miliaressis
Mar 18, 1999·Pharmacology, Biochemistry, and Behavior·V M CastilhoM L Brandão

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