PMID: 1965723Jan 1, 1990

A reinvestigation of the reaction of desferrioxamine with superoxide radicals. A pulse radiolysis study

Free Radical Research Communications
S Goldstein, G Czapski

Abstract

The reaction of desferrioxamine with superoxide has been studied using the pulse radiolysis technique. The decay of O2- was not accelerated in the presence of up to 4 x 10(-4) M desferrioxamine at physiological pH. The rate constant was found to be lower than 2 x 10(4) M-1s-1. In acid solutions the rate constant of the reaction between desferrioxamine and HO'2 was found to be lower than 10(5) M-1s-1. The reaction was not studied in alkaline solutions due to the high absorbance of desferrioxamine in the U.V. region. The pK of desferrioxamine was determined to be 9.2 +/- 0.05.

References

Dec 1, 1989·International Journal of Radiation Biology·D SabouraultC Ferradini
Jan 1, 1988·Free Radical Biology & Medicine·S GoldsteinG Czapski
Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·S D AustC E Thomas
Oct 1, 1982·Archives of Biochemistry and Biophysics·J Butler, B Halliwell
May 15, 1984·Biochemical Pharmacology·J SinaceurR Nordmann
Jan 1, 1983·Critical Reviews in Clinical Laboratory Sciences·G D McLarenR W Kellermeyer
Apr 10, 1982·British Medical Journal·B ModellD J Weatherall
Jul 15, 1982·Chemico-biological Interactions·S HoeB Halliwell
Oct 7, 1964·Annals of the New York Academy of Sciences·H KEBERLE

Citations

Feb 21, 2004·Free Radical Biology & Medicine·Silvina BartesaghiRafael Radi
Mar 1, 2013·Oral Diseases·C M Shortt, K D O'Halloran

Related Concepts

Desferal
Edetic Acid, Sodium Salt
Free Radicals
Half-Life
Hydrogen-Ion Concentration
Pulse Radiolysis
Solutions
Spectrophotometry
Superoxides

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