A relationship between plasma renin activity and the rapid eye movement phase of sleep in man

The Journal of Clinical Endocrinology and Metabolism
P E MullenW S Peart

Abstract

The possible influence of the central nervous system on renin release was investigated by simultaneously monitoring the PRA and the changes of the sleep-wake cycle. Nine normal volunteers were studied, 2 of whom were subjected to an acute sleep reversal procedure. PRA exhibited marked intra- and intersubject variability. No consistent diurnal or ultradian rhythm was observed. The nocturnal variation in PRA, however, was associated with changes in the stage of sleep. The rapid eye movement (REM) phase correlated with a decrease in PRA. In the 9 subjects, 26 measurements were made during REM, all but 2 of which showed a drop compared to the level obtained in the immediately preceding sleep stage (P less than 0.001), by two-tailed t test). The mean decrease in PRA accompanying REM was 407 pg/ml.h, and the mean time for PRA to decrease by half after REM onset was 33 min, with a SE of 8 min. The sleep reversal procedure confirmed that REM was associated with decreased PRA even when sleep occurred at an unaccustomed time. REM is demonstrated by these findings to be temporally associated with a suppression of PRA. The rate of decrease of PRA after REM onset closely approximates the most recent estimations of PRA half-life, which sugge...Continue Reading

Citations

Jun 15, 1987·Life Sciences·G BrandenbergerM Follenius
Sep 1, 1992·Journal of Sleep Research·B GoichotM Follenius
Mar 1, 1994·Journal of Sleep Research·G BrandenbergerM Follenius
Apr 1, 1990·Hypertension·G BrandenbergerM Follenius
Aug 15, 1996·Annals of the New York Academy of Sciences·F PortaluppiC Fersini
Mar 1, 1983·The British Journal of Psychiatry : the Journal of Mental Science·P E Mullen
Jul 1, 1990·Journal of Endocrinological Investigation·G BrandenbergerM Follenius

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