A relationship between substance P receptor and retinal fibers in the rat suprachiasmatic nucleus

Brain Research
K TakatsujiM Tohyama

Abstract

The suprachiasmatic nucleus (SCN) in the hypothalamus controls many of the circadian rhythms in mammalian species. In the present study, we investigated the location of substance P receptor (SPR)-containing neurons in the rat SCN, using a specific antibody against SPR, which corresponds to the NK-1 subtype of tachykinin receptors, and also examined the synaptic relationship between SPR-containing neurons and retinal fibers at the ultrastructural level. An SPR-immunoreactive meshwork of labeled somata and dendrites was identified in the SCN. The strongest SPR-immunoreactivity was observed in the dorsal and lateral parts of the SCN. Many labeled somata were identified there and their dendrites protruded ventrally from their somata. A few SPR-immunoreactive somata were observed also in the ventral part of the SCN and within the optic tract. In the SCN of eye-enucleated animals, degenerating retinal fibers were shown to terminate on SPR-immunoreactive dendrites forming asymmetrical axo-dendritic contacts.

References

Mar 31, 1988·Neuroscience Letters·J H MeijerM Dietz
Sep 1, 1972·The Journal of Comparative Neurology·R Y Moore, N J Lenn
Apr 1, 1993·Brain Research. Molecular Brain Research·H MaenoM Tohyama
Apr 1, 1993·The European Journal of Neuroscience·M CastelJ Storm-Mathisen
Jan 1, 1994·Brain Research. Molecular Brain Research·G MickM Tohyama

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Citations

Oct 28, 1999·Brain Research. Developmental Brain Research·H OyamadaM Tohyama
Apr 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cassandra VanDunkPaul A Gray
Aug 31, 2002·Microscopy Research and Technique·Tetsuya Goto, Teruo Tanaka
Dec 13, 2005·Brain Research Reviews·L P Morin, C N Allen

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