A Remarkably Simple Class of Imidazolium-Based Lipids and Their Biological Properties

Chemistry : a European Journal
Da WangHans-Joachim Galla

Abstract

A series of imidazolium salts bearing two alkyl chains in the backbone of the imidazolium core were synthesized, resembling the structure of lipids. Their antibacterial activity and cytotoxicity were evaluated using Gram-positive and Gram-negative bacteria and eukaryotic cell lines including tumor cells. It is shown that the length of alkyl chains in the backbone is vital for the antibiofilm activities of these lipid-mimicking components. In addition to their biological activity, their surface activity and their membrane interactions are shown by film balance and quartz crystal microbalance (QCM) measurements. The structure-activity relationship indicates that the distinctive chemical structure contributes considerably to the biological activities of this novel class of lipids.

References

Jan 9, 1999·Clinical Microbiology Reviews·G McDonnell, A D Russell
Nov 1, 2003·Science·Robin D Rogers, Kenneth R Seddon
May 24, 2007·Chemical Reviews·Vasile I Pârvulescu, Christopher Hardacre
Jun 15, 2007·Chemical Reviews·Fred van Rantwijk, Roger A Sheldon
Jul 26, 2008·Physical Chemistry Chemical Physics : PCCP·Na LiLi Yu
Sep 17, 2010·Angewandte Chemie·Kalluri V S RanganathFrank Glorius
Apr 8, 2011·Chemical Reviews·Jason P Hallett, Tom Welton
Feb 14, 2014·Chemical Communications : Chem Comm·Christian RichterBart Jan Ravoo
Jun 27, 2014·Nature·Matthew N HopkinsonFrank Glorius
Dec 18, 2014·Accounts of Chemical Research·Michèle Soleilhavoup, Guy Bertrand
Aug 19, 2015·Chemistry : a European Journal·Andreas RühlingFrank Glorius

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Citations

Oct 13, 2015·Biochemical and Biophysical Research Communications·Da WangHans-Joachim Galla
Dec 10, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Patrick DrückerHans-Joachim Galla
Oct 12, 2016·Chemistry : a European Journal·Andreas RühlingFrank Glorius
Feb 10, 2017·Chemistry : a European Journal·Benedict KemperPol Besenius
Jan 6, 2018·Biophysics Reviews·Da WangPatrick Drücker
Jul 26, 2018·Physical Chemistry Chemical Physics : PCCP·Manuel M NeidhardtSabine Laschat
Mar 20, 2018·Biophysics Reviews·Lena Rakers, Frank Glorius
Apr 28, 2020·Physical Chemistry Chemical Physics : PCCP·Steffen BornemannRoland Winter
Jul 29, 2020·Chemistry : a European Journal·Tiffany O PaulischFrank Glorius
Dec 29, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Briana R SchrageChristopher J Ziegler
Dec 13, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·S MitraS K Ghosh
Dec 30, 2020·Pharmaceuticals·Adriana VallsBelén Altava
Mar 3, 2021·Biochimica Et Biophysica Acta. Biomembranes·Saheli MitraSajal Kumar Ghosh
Dec 10, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Da WangHans-Joachim Galla
Jun 8, 2018·The Journal of Physical Chemistry. B·Sandeep KumarVenus S Mithu
Jan 27, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Tahereh Ghaed-SharafMohammad Hadi Ghatee
Mar 7, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Antonio Benedetto, Pietro Ballone
Sep 4, 2021·Drug Delivery and Translational Research·Lijuan ZengWenting Song

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