A remotely operated drug delivery system with an electrolytic pump and a thermo-responsive valve

Biomicrofluidics
Ying YiIan G Foulds

Abstract

Implantable drug delivery devices are becoming attractive due to their abilities of targeted and controlled dose release. Currently, two important issues are functional lifetime and non-controlled drug diffusion. In this work, we present a drug delivery device combining an electrolytic pump and a thermo-responsive valve, which are both remotely controlled by an electromagnetic field (40.5 mT and 450 kHz). Our proposed device exhibits a novel operation mechanism for long-term therapeutic treatments using a solid drug in reservoir approach. Our device also prevents undesired drug liquid diffusions. When the electromagnetic field is on, the electrolysis-induced bubble drives the drug liquid towards the Poly (N-Isopropylacrylamide) (PNIPAM) valve that consists of PNIPAM and iron micro-particles. The heat generated by the iron micro-particles causes the PNIPAM to shrink, resulting in an open valve. When the electromagnetic field is turned off, the PNIPAM starts to swell. In the meantime, the bubbles are catalytically recombined into water, reducing the pressure inside the pumping chamber, which leads to the refilling of the fresh liquid from outside the device. A catalytic reformer is included, allowing more liquid refilling during ...Continue Reading

References

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Jul 23, 2015·Lab on a Chip·Ying YiIan G Foulds

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Citations

Oct 1, 2015·Biomicrofluidics·Brigitte Stadler
May 11, 2016·Sensors·Ahmed AlfadhelJürgen Kosel
Jun 24, 2016·Scientific Reports·Omar YassineJurgen Kosel
Nov 27, 2019·Micromachines·Xinjie Zhang, Ayobami Elisha Oseyemi

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