A Renewed Focus on the Association Between Thyroid Hormones and Lipid Metabolism

Frontiers in Endocrinology
Leonidas H Duntas, Gabriela Brenta

Abstract

Thyroid dysfunction, manifesting as either overt or subclinical hypothyroidism, negatively affects lipid metabolism: this leads to hypercholesterolemia which progressively increases the risk for cardiovascular disease and, potentially, mortality. Hypercholesterolemia in hypothyroidism is mainly due to a reduction in low-density lipoprotein (LDL) receptor activity, this accompanied by concomitant diminishing control by triiodothyronine (T3) of sterol regulatory element-binding protein 2 (SREBP-2), which modulates cholesterol biosynthesis by regulating rate-limit degrading enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) activity. Recently, 3,5-diiodothyronine (T2), a natural thyroid hormone derivative, was found to repress the transcription factor carbohydrate-response element-binding protein (ChREBP) and also to be involved in lipid catabolism and lipogenesis, though via a different pathway than that of T3. While thyroid hormone could therapeutically reverse the dyslipidemic profile commonly occurring in hypothyroidism, it should be borne in mind that the potency of the effects may be age-and sex-dependent. Thyroid hormone administration possibly also sustains and enhances the efficacy of hypolipidemic drugs, su...Continue Reading

References

Jan 1, 1988·The Journal of Clinical Endocrinology and Metabolism·T KuusiE A Nikkilä
Jan 1, 1987·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S Valdemarsson, P Nilsson-Ehle
Aug 1, 1972·The Journal of Clinical Investigation·E A Nikkilä, M Kekki
Dec 31, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·K NakajimaE Campos
Mar 1, 2000·Archives of Internal Medicine·G J CanarisE C Ridgway
May 30, 2002·Thyroid : Official Journal of the American Thyroid Association·Leonidas H Duntas
Oct 15, 2003·The Journal of Clinical Endocrinology and Metabolism·Frank M Sacks, Hannia Campos
Sep 3, 2004·Journal of Lipid Research·Greetje J de GroothJan Albert Kuivenhoven
Oct 27, 2004·The American Journal of Medicine·Mitsuru ItoToshiaki Hanafusa
Jun 9, 2005·The Journal of Biological Chemistry·Xavier PrieurJoan C Rodríguez
Mar 1, 2006·The Journal of Biological Chemistry·Charlotte FugierPhilippe Delerive
Dec 7, 2006·The Journal of Clinical Endocrinology and Metabolism·Mitsuru ItoAkira Miyauchi
Jun 5, 2007·Thyroid : Official Journal of the American Thyroid Association·Gabriela BrentaLaura Schreier
Aug 2, 2007·Annual Review of Genetics·Peter J Espenshade, Adam L Hughes
Sep 29, 2007·Thyroid : Official Journal of the American Thyroid Association·Leonidas H Duntas, Leonard Wartofsky
Jul 1, 2008·Atherosclerosis. Supplements·Harry R DavisScott W Altmann
Nov 19, 2008·Thyroid : Official Journal of the American Thyroid Association·Gabriela BrentaLaura Schreier
Jul 10, 2010·Thyroid : Official Journal of the American Thyroid Association·Signe GjeddeNiels Møller
Oct 23, 2010·Therapeutic Advances in Cardiovascular Disease·Freij A Gobal, Jawahar L Mehta
Apr 21, 2011·Endocrine Journal·Tetsuya TagamiUNKNOWN PHPH study group
Aug 10, 2011·Journal of Cellular Physiology·Gabriele V GnoniLuisa Siculella
Dec 23, 2011·Clinical Endocrinology·Avantika C WaringUNKNOWN Health, Ageing, and Body Composition (Health ABC) Study
Jan 13, 2012·The Journal of Clinical Endocrinology and Metabolism·Elisa FabbriniSamuel Klein
Mar 27, 2012·The Medical Clinics of North America·Leonidas H Duntas, Gabriela Brenta
Aug 7, 2012·European Journal of Internal Medicine·Senay ArikanDeniz Gokalp
Sep 6, 2012·Endocrinology·Ira J GoldbergJoel R Ehrenkranz
Oct 12, 2012·Thyroid : Official Journal of the American Thyroid Association·Sara TogniniFabio Monzani
Oct 25, 2012·European Journal of Endocrinology·Nathalie E HeimaSuat Simsek
Oct 31, 2012·Thyroid : Official Journal of the American Thyroid Association·Arjan J KwakernaakRobin P F Dullaart
Dec 19, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jeffrey R GarberUNKNOWN American Association of Clinical Endocrinologists and American Thyroid Association Taskforce on Hypothyroidism in Adults
Jun 19, 2013·Indian Journal of Endocrinology and Metabolism·Girish RapartiJaiprakash Ramanand
Jul 6, 2013·Arquivos brasileiros de endocrinologia e metabologia·Gabriela BrentaUNKNOWN Task Force on Hypothyroidism of the Latin American Thyroid Society (LATS)
Aug 21, 2013·Biochimica Et Biophysica Acta·Alessio RochiraLuisa Siculella
Nov 13, 2013·JAMA Internal Medicine·Devina L WillardElizabeth N Pearce
Nov 19, 2013·Journal of the American College of Cardiology·Neil J StoneUNKNOWN American College of Cardiology/American Heart Association Task Force on Practice Guidelines
Jan 28, 2014·Cardiovascular Diabetology·Jean-Charles FruchartUNKNOWN Residual Risk Reduction Initiative (R3i)

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Citations

Aug 1, 2019·Thyroid : Official Journal of the American Thyroid Association·Benjamin Van TassellFrancesco S Celi
Dec 13, 2019·Toxicologic Pathology·June K DunnickArun Kumar R Pandiri
Sep 5, 2019·Endocrine·Leonidas H Duntas, Paul Michael Yen
Apr 5, 2019·Disease Markers·Eliza ChristopoulouTheodosios Filippatos
Jan 11, 2020·Frontiers in Endocrinology·Rade VukovicJelena Vekic
Aug 23, 2020·International Journal of Molecular Sciences·Daniela Maria TanaseMariana Floria
Jun 4, 2020·Therapeutic Advances in Endocrinology and Metabolism·Patrícia de Fátima Dos Santos TeixeiraCarmen Cabanelas Pazos-Moura
Feb 2, 2020·Nature Reviews. Endocrinology·Antonio C Bianco, Peter Taylor
Aug 1, 2020·Frontiers in Endocrinology·Ritu Madan, Francesco S Celi
Jun 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Afshan MasoodAssim A Alfadda
Jun 14, 2020·International Journal of Molecular Sciences·Marco GiammancoItalia Di Liegro
Dec 16, 2020·Archives of Endocrinology and Metabolism·José Augusto Sgarbi, Laura Sterian Ward
Jun 24, 2020·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Liu LuxiaSong Pei
Dec 8, 2020·Molecular Metabolism·Sharon O Jensen-Cody, Matthew J Potthoff
Mar 18, 2021·Praxis·Monika RauBeat Knechtle
Apr 17, 2021·International Journal of Endocrinology·Sanjay KalraDeepak Khandelwal
Jun 19, 2021·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Ozge KurtkulagiGulali Aktas

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