A report of supratentorial leptomeningeal hemangioblastoma and a literature review

Neuropathology : Official Journal of the Japanese Society of Neuropathology
Hiroaki TakeuchiToshihiko Kubota

Abstract

Hemangioblastomas of the CNS are solid or cystic vascular-rich tumors, most common in the cerebellum, less frequent in the brainstem or spinal cord, and rare in supratentorial locations with meningeal involvement. We document a case in a 58-year-old man who presented with about 2 months history of motor weakness and speech dysfunction. The tumor was a heterogeneously enhanced dural-based tumor with high vascularity and perifocal edema in the left frontal lobe. The tumor was completely removed followed by embolization and preoperative radiotherapy. Histologic examination revealed a hemangioblastoma with features resembling angiomatous meningioma. Immunohistochemistry for epithelial membrane antigen (EMA) and S100 may be helpful to make differential diagnosis. Electron microscopic investigation is essential to differentiate between meningiomas and other leptomeningeal tumors.

References

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Citations

Jul 22, 2010·Neurosurgery·Matthieu PeyreUNKNOWN French NCI Network VHL Disease and Inherited Predisposition to Kidney Cancer
Nov 29, 2012·Journal of Neurosciences in Rural Practice·Avijit Sarkari, Deepak Agrawal
Aug 14, 2012·Pathology, Research and Practice·Valeria BarresiGiovanni Tuccari
Jan 18, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Denes B HorvathyAdnan H Siddiqui
Mar 27, 2012·The American Journal of Surgical Pathology·Valeria BarresiGaetano Barresi
Dec 1, 2017·Advances in Anatomic Pathology·Michele BiscegliaCarlos E Bacchi

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