A report on the effect of commencing enfuvirtide on peripheral neuropathy

AIDS Research and Human Retroviruses
Catherine L CherryBruce J Brew

Abstract

Enfuvirtide is the first fusion inhibitor approved for use in HIV treatment and is a useful therapeutic option for highly treatment experienced individuals. Passive reporting has associated increased neuropathy rates with enfuvirtide use in some early studies but not others. The aim of this study was to describe any functional or clinical changes consistent with neuropathy among enfuvirtide users. A prospective cohort study of patients commencing or continuing enfuvirtide at a state HIV referral service, including clinical and sensory threshold monitoring, was conducted. A total of 14 patients were studied. All had advanced HIV disease and 13 (93%) had symptoms and/or signs consistent with neuropathy at baseline. Patients who entered the study on enfuvirtide-based therapy remained neurologically stable throughout follow-up. Eleven patients were assessed preand postenfuvirtide. No evidence was found for any clear effect of enfuvirtide on neuropathic symptoms, neuropathic signs, or sensory thresholds at a cohort level (p > 0.3 for all, Wilcoxon signed rank test). However, three (21%) patients experienced worsening of existing neuropathy symptoms (transient in two cases) and two (14%) patients' symptoms improved with enfuvirtide c...Continue Reading

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Citations

Dec 24, 2013·CNS Drugs·Michael S AbersJoseph S Kass
Oct 2, 2015·Journal of Neuropathology and Experimental Neurology·Jamie L DorseyJoseph L Mankowski
Jul 2, 2016·Neurotoxicity Research·Ankit ShahAnil Kumar
Aug 7, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Nina Y Yuan, Marcus Kaul
Dec 12, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Tyler LanmanRonald Ellis

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