A repository of bio-specimens from Mayak workers exposed to protracted radiation

Health Physics
Klara MuksinovaRuth Neta

Abstract

A repository of bio-specimens that includes organs from 700 deceased workers employed at the first nuclear weapons facility "Mayak" and donations of blood, buccal cells, and tissues removed at the time of surgery and/or biopsy from the members of the Mayak cohort undergoing medical treatment or diagnostic procedures has been established at the Southern Ural Biophysics Institute, in Ozyorsk, Russian Federation. The autopsied tissues include formaline-preserved organs, paraffin blocks, and histology slides. For all, occupational, dosimetry, and detailed medical information is available. For 359 individuals, information on malignant tumors, i.e., lung (171), stomach (51), liver (28), and intestine (19), as well as 32 cases of leukemia, are available. External gamma exposures are known for 95% of the 700 autopsies, of whom 560 were exposed to protracted doses exceeding 0.5 Gy, with known maximum annual doses ranging from 0.01-0.5 Gy for about 46%, and annual doses exceeding 0.5 Gy for 48%. Plutonium body burden is known for 73%, of which 40% had body burden greater than 1.5 kBq, and 15% of individuals had body burdens greater than 11.85 kBq. Newly collected specimens include frozen lymphocytes, EBV-immortalized B-cells, frozen eryt...Continue Reading

References

Mar 1, 1994·The Science of the Total Environment·N D OkladnikovaV N Doshchenko
Aug 27, 2002·Radiation Protection Dosimetry·R A GuilmetteY V Zaytseva
Apr 8, 2003·American Journal of Human Genetics·M Prakash HandeDavid J Brenner
May 20, 2003·Radiation Research·N S ShilnikovaN A Koshurnikova
Oct 7, 2003·Radiation Protection Dosimetry·F F HahnY V Lyovkina
May 27, 2004·Radiation Research·F F HahnY Zaytseva

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