We have developed a tetracycline-repressible female-specific lethal genetic system in the vinegar fly Drosophila melanogaster. One component of the system is the tetracycline-controlled transactivator gene under the control of the fat body and female-specific transcription enhancer from the yolk protein 1 gene. The other component consists of the proapoptotic gene hid under the control of a tetracycline-responsive element. Males and females of a strain carrying both components are viable on medium supplemented with tetracycline, but only males survive on normal medium. A strain with such properties would be ideal for a sterile-insect release program, which is most effective when only males are released in the field.
Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase
A germline transformation analysis reveals flexibility in the organization of heat shock consensus elements
Two independent cis-acting elements regulate the sex- and tissue-specific expression of yp3 in Drosophila melanogaster
20-Hydroxyecdysone, but not juvenile hormone, regulation of yolk protein gene expression can be mapped to cis-acting DNA sequences
Cooperative functions of the reaper and head involution defective genes in the programmed cell death of Drosophila central nervous system midline cells
Stable transformation of the yellow fever mosquito, Aedes aegypti, with the Hermes element from the housefly
The lepidopteran transposon vector, piggyBac, mediates germ-line transformation in the Mediterranean fruit fly
Distinct cell killing properties of the Drosophila reaper, head involution defective, and grim genes
Biochemical and genetic interactions between Drosophila caspases and the proapoptotic genes rpr, hid, and grim
Glossina austeni (Diptera: Glossinidae) eradicated on the island of Unguja, Zanzibar, using the sterile insect technique
Improved stability of genetic sex-separation strains for the Mediterranean fruit fly, Ceratitis capitata
Pro-apoptotic cell death genes, hid and reaper, from the tephritid pest species, Anastrepha suspensa
Organisation and expression of a cluster of yolk protein genes in the Australian sheep blowfly, Lucilia cuprina
Bactrocera tryoni and closely related pest tephritids--molecular analysis and prospects for transgenic control strategies
Understanding and improving transgene stability and expression in insects for SIT and conditional lethal release programs
Progress towards the development of a transgenic strain of the Australian sheep blowfly (Lucilia cuprina) suitable for a male-only sterile release program
Preservation of a transgenic strain of the sawfly, Athalia rosae (Hymenoptera) by artificial fertilization using cryopreserved sperm
A comprehensive gene expression atlas of sex- and tissue-specificity in the malaria vector, Anopheles gambiae
Conservation and sex-specific splicing of the transformer gene in the calliphorids Cochliomyia hominivorax, Cochliomyia macellaria and Lucilia sericata
A reduce and replace strategy for suppressing vector-borne diseases: insights from a deterministic model
Modeling the dynamics of a non-limited and a self-limited gene drive system in structured Aedes aegypti populations
Perspective on the combined use of an independent transgenic sexing and a multifactorial reproductive sterility system to avoid resistance development against transgenic Sterile Insect Technique approaches
Australian endemic pest tephritids: genetic, molecular and microbial tools for improved Sterile Insect Technique
CRISPR/Cas9-mediated mutagenesis of the white and Sex lethal loci in the invasive pest, Drosophila suzukii
Transgenic sexing system for Ceratitis capitata (Diptera: Tephritidae) based on female-specific embryonic lethality
Establishment of an RTA-Bddsx hybrid system for female-specific splicing that can affect the sex ratio of Bactrocera dorsalis (Hendel) after embryonic injection
Efficient germ-line transformation of the economically important pest species Lucilia cuprina and Lucilia sericata (Diptera, Calliphoridae)
Comparing the refuge strategy for managing the evolution of insect resistance under different reproductive strategies
Morphological characterization and molecular mapping of an irradiation-induced Speckled mutant in the silkworm, Bombyx mori
Comparative analysis of binary expression systems for directed gene expression in transgenic insects
Enhancing the stability and ecological safety of mass-reared transgenic strains for field release by redundant conditional lethality systems
piggyBac transformation of the New World screwworm, Cochliomyia hominivorax, produces multiple distinct mutant strains
Gene structure and expression of nanos (nos) and oskar (osk) orthologues of the vector mosquito, Culex quinquefasciatus
Organization and expression of the Australian sheep blowfly (Lucilia cuprina) hsp23, hsp24, hsp70 and hsp83 genes
Introduction of the RTA-Bddsx gene induces female-specific lethal effects in transformed Bactrocera dorsalis (Hendel)
Antipathogen genes and the replacement of disease-vectoring mosquito populations: a model-based evaluation
Functional characterization of calliphorid cell death genes and cellularization gene promoters for controlling gene expression and cell viability in early embryos
The Anopheles arabiensis genetic sexing strain ANO IPCL1 and its application potential for the sterile insect technique in integrated vector management programmes
Towards mosquito sterile insect technique programmes: exploring genetic, molecular, mechanical and behavioural methods of sex separation in mosquitoes
Effects of irradiation on Mediterranean fruit flies (Diptera: Tephritidae): emergence, survivorship, lure attraction, and mating competition
Genetically Engineered Ricin Suppresses Bactrocera dorsalis (Diptera: Tephritidae) based on Demographic Analysis of Group-Reared Life Table
Dosage Compensation of X-Linked Muller Element F Genes but Not X-Linked Transgenes in the Australian Sheep Blowfly
Mitonuclear interactions, mtDNA-mediated thermal plasticity, and implications for the Trojan Female Technique for pest control
Aseptic Rearing and Infection with Gut Bacteria Improve the Fitness of Transgenic Diamondback Moth, Plutella xylostella
Specific Gene Disruption in the Major Livestock Pests Cochliomyia hominivorax and Lucilia cuprina Using CRISPR/Cas9
Developing CRISPR-based sex-ratio distorters for the genetic control of fruit fly pests: A how to manual
Functional characterization of the cis-regulatory region for the vitellogenin gene in Plutella xylostella
Knocking down the sex peptide receptor by dsRNA feeding results in reduced oviposition rate in olive fruit flies
Genetic Variation and Potential for Resistance Development to the tTA Overexpression Lethal System in Insects
Genome Editing of Wnt-1, a Gene Associated with Segmentation, via CRISPR/Cas9 in the Pine Caterpillar Moth, Dendrolimus punctatus
Effects of stable ectopic expression of the primary sex determination gene Yob in the mosquito Anopheles gambiae
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
Synthetic Genetic Array Analysis
Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.
Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.
Neural Activity: Imaging
Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.
Chronic Fatigue Syndrome
Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.
Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.
Cell Atlas of the Human Eye
Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.
Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.
STING Receptor Agonists
Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.