PMID: 9255711Jul 1, 1997Paper

A residence-time distribution analysis of the hydrodynamics within the intestine in man during a regional single-pass perfusion with Loc-I-Gut: in-vivo permeability estimation

The Journal of Pharmacy and Pharmacology
Hans LennernäsGordon L Amidon

Abstract

The goal of this study was to determine the most appropriate hydrodynamic model for the Loc-I-Gut in-vivo perfusion system. The general mixing-tank-in-series model, which can approximate single mixing tank and laminar and plug-flow hydrodynamics, was fitted to the observed experimental residence-time distribution curves for the non-absorbable marker [14C]PEG 4000. The residence-time distribution analysis shows that the hydrodynamics of the perfusion solution within the jejunal segment in man is well approximately by a model containing on average between 1-2 mixing tanks in series. The solution is well mixed when using perfusion rates of 2.0, 3.0 and 6.0 mL min-1. The average mean residence time estimates from the fitted residence-time distribution were 12 +/- 7.6, 15 +/- 4.2 and 7.7 +/- 4.6 min, respectively, at these three perfusion rates. The mean volumes of the segment (Vs) were 25 +/- 15, 45 +/- 12 and 46 +/- 27 mL, respectively. There were no statistical differences between 2.0, 3.0 and 6.0 mL min-1 in respect of the number of mixing tanks (n) and mean residence times. This residence-time distribution analysis indicates that the luminal fluid in the Loc-I-Gut perfusion system is well-mixed, and that permeability calculatio...Continue Reading

References

Oct 1, 1992·Pharmaceutical Research·H LennernäsL K Paalzow
Dec 1, 1980·Journal of Pharmaceutical Sciences·G L AmidonE N Lightfoot
Aug 1, 1994·The American Journal of Physiology·M B LandeM L Zeidel
Mar 1, 1993·British Journal of Clinical Pharmacology·H LennernäsL K Paalzow
Sep 1, 1996·Pharmaceutical Research·U FagerholmH Lennernäs
Jul 1, 1997·The Journal of Pharmacy and Pharmacology·H Lennernäs

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Citations

Dec 13, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·L BønløkkeH Lennernäs
Jun 16, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·N J ClearI Wilding
Mar 30, 2002·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·H LennernäsG L Amidon
Mar 11, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·L BønløkkeH Lennernäs
Apr 22, 2009·The AAPS Journal·Masoud JameiGeoffrey Tucker
Jan 13, 2010·Expert Opinion on Drug Metabolism & Toxicology·Jianling Wang, Suzanne Skolnik
Nov 27, 2004·The Journal of Pharmacy and Pharmacology·Takashi MizumaMasahiro Hayashi
Feb 13, 2003·British Journal of Clinical Pharmacology·Christer TannergrenHans Lennernäs
Oct 31, 2007·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H Lennernäs
Nov 26, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Arik DahanGordon L Amidon
Aug 31, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Hans Lennernäs
Jul 1, 1997·The Journal of Pharmacy and Pharmacology·H Lennernäs
Apr 21, 1998·Journal of Pharmaceutical Sciences·H Lennernäs

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