A resorbable antibiotic eluting bone void filler for periprosthetic joint infection prevention

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Zachary JonesKristofer D Sinclair

Abstract

Periprosthetic joint infection (PJI) following total knee arthroplasty is a globally increasing procedural complication. These infections are difficult to treat and typically require revision surgery. Antibiotic-loaded bone cement is frequently utilized to deliver antibiotics to the site of infection; however, bone cement is a nondegrading foreign body and known to leach its antibiotic load, after an initial burst release, at subtherapeutic concentrations for months. This work characterized a resorbable, antibiotic-eluting bone void filler designed to restore bone volume and prevent PJI. Three device formulations were fabricated, consisting of different combinations of synthetic inorganic bone graft material, degradable polymer matrices, salt porogens, and antibiotic tobramycin. These formulations were examined to determine the antibiotic's elution kinetics and bactericidal potential, the device's degradation in vitro, as well as osteoconductivity and device resorption in vivo using a pilot rabbit bone implant model. Kirby-Bauer antibiotic susceptibility tests assessed bactericidal activity. Liquid chromatography with tandem mass spectrometry measured antibiotic elution kinetics, and scanning electron microscopy was used to qua...Continue Reading

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Citations

Jan 19, 2020·International Journal of Molecular Sciences·Sho OshimaMasanori Kikuchi
Nov 20, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Chang-Chin WuKai-Chiang Yang
Nov 11, 2021·Drug Delivery·Reem Khaled WassifSeham A Elkheshen

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