Abstract
Periprosthetic joint infection (PJI) following total knee arthroplasty is a globally increasing procedural complication. These infections are difficult to treat and typically require revision surgery. Antibiotic-loaded bone cement is frequently utilized to deliver antibiotics to the site of infection; however, bone cement is a nondegrading foreign body and known to leach its antibiotic load, after an initial burst release, at subtherapeutic concentrations for months. This work characterized a resorbable, antibiotic-eluting bone void filler designed to restore bone volume and prevent PJI. Three device formulations were fabricated, consisting of different combinations of synthetic inorganic bone graft material, degradable polymer matrices, salt porogens, and antibiotic tobramycin. These formulations were examined to determine the antibiotic's elution kinetics and bactericidal potential, the device's degradation in vitro, as well as osteoconductivity and device resorption in vivo using a pilot rabbit bone implant model. Kirby-Bauer antibiotic susceptibility tests assessed bactericidal activity. Liquid chromatography with tandem mass spectrometry measured antibiotic elution kinetics, and scanning electron microscopy was used to qua...Continue Reading
References
May 1, 1994·Journal of Biomedical Materials Research·R D BloebaumA A Hofmann
Mar 1, 1993·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·C T LaurencinR Langer
Jan 7, 1998·Journal of Orthopaedic Trauma·R P MeinigS Gogolewski
Aug 12, 1998·The Journal of Bone and Joint Surgery. British Volume·J W PowlesA M Lovering
May 11, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T HiranoJ M Hock
May 21, 1999·Science·J W CostertonE P Greenberg
Nov 22, 2001·Clinical Orthopaedics and Related Research·K J HendricksJ O Anglen
Apr 4, 2002·Acta Orthopaedica Scandinavica·Thomas B JensenKjeld Søballe
Sep 5, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Brian G KeevilDonald P Cooper
Aug 1, 1959·A.M.A. Archives of Internal Medicine·A W BAUERW M KIRBY
Oct 17, 2003·European Cells & Materials·P A Gunatillake, R Adhikari
Mar 17, 2004·International Journal of Pharmaceutics·Xin WangGuy Van den Mooter
May 5, 2004·Clinical Orthopaedics and Related Research·Catherine G AmbroseAntonios G Mikos
Jun 8, 2004·Acta Orthopaedica Scandinavica·Matthew D A FletcherAndrew M Lovering
Jul 28, 2004·Lancet·Daniel P Lew, Francis A Waldvogel
Feb 22, 2005·Critical Reviews in Therapeutic Drug Carrier Systems·Indu BalaM N V Ravi Kumar
Mar 1, 2006·BMC Musculoskeletal Disorders·Hein P StallmannPaul I J M Wuisman
Jun 29, 2006·Current Opinion in Infectious Diseases·Andrej Trampuz, Andreas F Widmer
Jan 20, 2007·Journal of Biomedical Materials Research. Part a·R D BloebaumA A Hofmann
Jan 30, 2007·The Journal of Bone and Joint Surgery. British Volume·T B JensenK Søballe
Oct 30, 2009·Journal of the Royal Society, Interface·Viviana Mouriño, Aldo R Boccaccini
Dec 31, 2009·Journal of Biomaterials Science. Polymer Edition·Andrea E HafemanScott A Guelcher
May 14, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Christopher R RathboneJoseph C Wenke
Jul 22, 2011·The Journal of Bone and Joint Surgery. American Volume·Kevin L Garvin, Beau S Konigsberg
May 5, 2012·The Journal of Arthroplasty·Steven M KurtzJavad Parvizi
Apr 9, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Kristofer D SinclairRoy D Bloebaum
Jan 1, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Benjamin D BrooksAmanda E Brooks
Mar 31, 2015·PloS One·Benjamin D BrooksAmanda E Brooks
Citations
Jan 19, 2020·International Journal of Molecular Sciences·Sho OshimaMasanori Kikuchi
Jun 30, 2016·Polymers·John CurleyAmanda E Brooks
Nov 20, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Chang-Chin WuKai-Chiang Yang
Nov 11, 2021·Drug Delivery·Reem Khaled WassifSeham A Elkheshen