A resource for the assessment of lung nodule size estimation methods: database of thoracic CT scans of an anthropomorphic phantom.

Optics Express
Marios A GavrielidesNicholas Petrick

Abstract

A number of interrelated factors can affect the precision and accuracy of lung nodule size estimation. To quantify the effect of these factors, we have been conducting phantom CT studies using an anthropomorphic thoracic phantom containing a vasculature insert to which synthetic nodules were inserted or attached. Ten repeat scans were acquired on different multi-detector scanners, using several sets of acquisition and reconstruction protocols and various nodule characteristics (size, shape, density, location). This study design enables both bias and variance analysis for the nodule size estimation task. The resulting database is in the process of becoming publicly available as a resource to facilitate the assessment of lung nodule size estimation methodologies and to enable comparisons between different methods regarding measurement error. This resource complements public databases of clinical data and will contribute towards the development of procedures that will maximize the utility of CT imaging for lung cancer screening and tumor therapy evaluation.

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Citations

Oct 23, 2012·Academic Radiology·Marios A GavrielidesNicholas Petrick
Apr 29, 2014·Translational Oncology·Binsheng ZhaoLin Lu
Mar 26, 2015·Journal of Digital Imaging·Jean-François Pambrun, Rita Noumeir
Jun 22, 2010·IEEE Transactions on Medical Imaging·Marios A GavrielidesNicholas Petrick
Aug 8, 2013·Medical Image Analysis·Rina D RudyantoArrate Muñoz-Barrutia
Jun 12, 2016·Academic Radiology·Xiaonan MaAndrew J Buckler
Jul 22, 2016·Journal of Digital Imaging·José Raniery Ferreira JuniorPaulo Mazzoncini de Azevedo-Marques
Dec 15, 2017·Medical Physics·Anthony P ReevesShuang Liu
Sep 14, 2019·Journal of Digital Imaging·Maryam Gholizadeh-AnsariPaul Babyn
Sep 8, 2011·Physics in Medicine and Biology·Rongping ZengKyle J Myers
Sep 20, 2017·Scientific Data·Fred PriorJohn Freymann
Jan 12, 2021·BioMed Research International·Shi QiuTing Liang
Nov 23, 2020·Computer Methods and Programs in Biomedicine·Wookjin ChoiWei Lu
Mar 12, 2021·Tomography : a Journal for Imaging Research·Lin LuBinsheng Zhao

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