A responsive particulate MRI contrast agent for copper(I): a cautionary tale.

Dalton Transactions : an International Journal of Inorganic Chemistry
Eric D SmolenskyValérie C Pierre

Abstract

A responsive MION-based MRI contrast agent for the detection of copper(I) is presented. Induced agglomeration of azide and acetylene-functionalized magnetite nanoparticles via Cu(I)-catalysed Huisgen cycloaddition leads to significant decrease in longitudinal relaxivity due to the slow exchange of water molecules trapped within the cluster with bulk solvent. Agglomeration leads to an initial two-fold increase followed by a sharp and almost complete loss in transverse relaxivity for clusters larger than 200 nm in size. The decrease in r(2) for clusters reaching the static dephasing regime has two significant implications for particulate responsive MRI contrast agents. First, the maximum increase in r(2) is barely two-fold, second, since r(2) does not increase continuously with increasing cluster size, the r(1)/r(2) ratio cannot be used to determine the concentration of an analyte ratiometrically.

References

Jul 4, 2001·Journal of Magnetic Resonance Imaging : JMRI·A RochP Gillis
Jan 26, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Pierre GillisRodney A Brooks
Jul 23, 2002·Nature Biotechnology·J Manuel PerezRalph Weissleder
Apr 3, 2003·Angewandte Chemie·Ming ZhaoRalph Weissleder
Aug 21, 2003·Journal of the American Chemical Society·J Manuel PerezRalph Weissleder
Jan 8, 2004·Journal of the American Chemical Society·Shouheng SunGuanxiong Li
Jul 7, 2005·Journal of the American Chemical Society·Benjamin L FrankampVincent M Rotello
Oct 19, 2005·Investigative Radiology·Martin RohrerHanns-Joachim Weinmann
Aug 31, 2006·Journal of the American Chemical Society·Romain F H Viguier, Alison N Hulme
Dec 15, 2006·Journal of the American Chemical Society·Emily L Que, Christopher J Chang
Feb 13, 2007·Journal of the American Chemical Society·Michael D ShultzEverett E Carpenter
Aug 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jody L MajorThomas J Meade
Oct 31, 2007·Journal of Magnetic Resonance Imaging : JMRI·Leslie E W LaConteGang Bao
Aug 14, 2008·Chemical Reviews·Morten Meldal, Christian Wenzel Tornøe
Jan 22, 2009·Contrast Media & Molecular Imaging·Carlos F G C Geraldes, Sophie Laurent
Jun 6, 2009·Journal of the American Chemical Society·Emily L QueChristopher J Chang
Dec 22, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Emily L QueChristopher J Chang
Jul 16, 2010·Journal of Neurochemistry·Zhiqiang ZhengMichael J Petris
Jul 16, 2010·American Journal of Alzheimer's Disease and Other Dementias·George J BrewerRobert Dick
Sep 3, 2001·Angewandte Chemie·Lee JosephsonRalph Weissleder

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Citations

Jul 3, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Eric D SmolenskyValérie C Pierre
Mar 19, 2016·Molecular Pharmaceutics·Katie R HurleyChristy L Haynes
May 23, 2013·Journal of the American Chemical Society·Eric D SmolenskyValérie C Pierre
Sep 27, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jinjin ZhangMichael Garwood
Jan 18, 2017·Inorganic Chemistry·Kriti SrivastavaValérie C Pierre
Aug 2, 2017·Nanomaterials·Debora BonvinMarijana Mionić Ebersold
Jun 14, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·K SrivastavaV C Pierre
Jan 13, 2015·Metallomics : Integrated Biometal Science·Levi A Ekanger, Matthew J Allen
Aug 21, 2020·Journal of the American Chemical Society·Sumin LeeChristopher J Chang

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