A Resting-State Functional MR Imaging and Spectroscopy Study of the Dorsal Hippocampus in the Chronic Unpredictable Stress Rat Model

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Ricardo MagalhãesFawzi Boumezbeur

Abstract

Exposure to chronic stress leads to an array of anatomical, functional, and metabolic changes in the brain that play a key role in triggering psychiatric disorders such as depression. The hippocampus is particularly well known as a target of maladaptive responses to stress. To capture stress-induced changes in metabolic and functional connectivity in the hippocampus, stress-resistant (low-responders) or -susceptible (high-responders) rats exposed to a chronic unpredictable stress paradigm (categorized according to their hormonal and behavioral responses) were assessed by multimodal neuroimaging; the latter was achieved by using localized 1H MR spectroscopy and resting-state functional MRI (fMRI) at 11,7T data from stressed (n = 25) but also control (n = 15) male Wistar rats.Susceptible animals displayed increased GABA-glutamine (+19%) and glutamate-glutamine (+17%) ratios and decreased levels of macromolecules (-11%); these changes were positively correlated with plasma corticosterone levels. In addition, the neurotransmitter levels showed differential associations with functional connectivity between the hippocampus and the amygdala, the piriform cortex and thalamus between stress-resistant and -susceptible animals. Our observ...Continue Reading

Citations

Mar 11, 2020·Frontiers in Aging Neuroscience·Marcelo FeboThomas C Foster
Feb 11, 2021·NMR in Biomedicine·Bernard LanzUNKNOWN Experts' Working Group on Magnetic resonance spectroscopy in the rodent brain
Feb 9, 2021·Frontiers in Aging Neuroscience·Joseph A McQuailThomas C Foster
Jun 25, 2021·Neurochemistry International·Si-Yu RenNai-Hong Chen

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