A resting-state study of volumetric and functional connectivity of the habenular nucleus in treatment-resistant depression patients

Brain and Behavior
Shuxin LuanChang Liu

Abstract

To investigate the volumetric and functional connectivity of the habenular nucleus in treatment-resistant depression (TRD) patients using the resting-state functional magnetic resonance imaging (rs-fMRI) approach. A total of 15 TRD patients, who visited the Mental Health Institute of the First Hospital Affiliated with Jilin University between August 2014 and March 2015, along with 15 normal subjects, were enrolled into this study for structural and functional imaging. Functional connectivity analysis was performed using bilateral habenular nuclei as the region of interest in contrast to whole-brain voxels. No significant difference of absolute volume was found in bilateral habenular nuclei between TRD patients and healthy controls, or after controlling for individual total intracranial volume. However, functional connectivity analysis showed increased connectivity between the right habenular nucleus with the medial superior frontal gyrus, anterior cingulate cortex and medial orbitofrontal gyrus, and decreased connectivity with the corpus callosum in the TRD group. For the left habenular nucleus seed, the brain region with increased functional connectivity in the inferior temporal gyrus and decreased functional connectivity in t...Continue Reading

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Citations

Oct 2, 2020·European Archives of Psychiatry and Clinical Neuroscience·Ulf J MüllerJohann Steiner
Nov 30, 2020·The International Journal of Neuropsychopharmacology·Ana Maria Rivas-GrajalesSanjay J Mathew

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Software Mentioned

AlphaSim
ITK
REST
SNAP3
‐ SNAP3
GRETNA
MATLAB

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