A retrospective analysis of allele frequency changes of major genes during 20 years of selection in the Italian Large White pig breed

Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie
Luca FontanesiLuca Buttazzoni

Abstract

In this study, we investigated whether a selection programme based on boar genetic evaluation obtained with a classical BLUP animal model can change allele frequencies in a pig population. All Italian Large White boars born from 1992 to 2012 with estimated breeding value reliability >0.85 (n = 200) were selected among all boars of this breed. Boars were genotyped with markers in major genes (IGF2 intron3-g.3072G>A, MC4R p.D298N, VRTN PRE1 insertion, PRKAG3 p.I199V and FTO g.276T>G). Genotyping data were analysed grouping boars in eight classes according to their year of birth. To evaluate the influence of time on allele frequencies of the genotyped markers, multinomial logistic regression models were computed. Four of five polymorphic sites (IGF2, MC4R, VRTN and FTO) showed significant (p < 0.01) changes in allele frequencies over time due to a progressive and continuous increase of one allele (associated with higher lean meat content, higher average daily gain and favourable feed: gain ratio) and, consequently, decrease of the other one, following the directional selection of the selection programme of this pig breed. The retrospective analysis that was carried out in Italian Large White boars suggests that selection based on ...Continue Reading

References

Feb 5, 2000·Mammalian Genome : Official Journal of the International Mammalian Genome Society·K S KimM F Rothschild
Feb 2, 2002·Nature Reviews. Genetics·N H Barton, P D Keightley
Oct 24, 2003·Nature·Anne-Sophie Van LaereLeif Andersson
Mar 27, 2007·International Journal of Biological Sciences·Max F RothschildZhihua Jiang
Jan 11, 2011·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·I A BomanD I Våge
Mar 2, 2012·Methods of Information in Medicine·A Groll, G Tutz
Mar 19, 2013·Trends in Genetics : TIG·Catherine W Ernst, Juan P Steibel

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Citations

Aug 5, 2017·Animal : an International Journal of Animal Bioscience·J RaoulJ M Elsen

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