A retrospective analysis of cases with neuroleptic malignant syndrome and an evaluation of risk factors for mortality

Turkish Journal of Emergency Medicine
Aynur SahinMualla Aylin Arici

Abstract

Neuroleptic malignant syndrome (NMS) is a neurological emergency rarely encountered in clinical practice but with a high mortality rate. Cases associated with atypical antipsychotic use or termination of dopamine agonists have been seen in recent years. The purpose of this study was to assess the presence of risk factors for mortality by investigating all clinical and laboratory characteristics of cases with NMS. This descriptive, cross-sectional study retrospectively investigated all clinical and laboratory characteristics by scanning the ICD-10 codes of patients presenting to the XXXX Faculty of Medicine Emergency Department and diagnosed with NMS between 2006 and 2016. Patients were divided into surviving and non-surviving groups, and the data elicited were subjected to statistical comparisons. The mean age of the 18 patients diagnosed with NMS was 46.9 ± 4.8 years, and 50% were women. In addition to antipsychotics among the drugs leading to NMS, the syndrome also developed as a result of levodopa withdrawal in three patients and metoclopramide use in one patient. Statistically significant differences were determined between the surviving and non-surviving patients in terms of blood pressure, blood urea nitrogen (BUN), creat...Continue Reading

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Citations

Apr 20, 2021·Expert Opinion on Drug Safety·Minghua TaoXin Tian
Aug 7, 2021·Acta Psychiatrica Scandinavica·Daniel GuinartChristoph U Correll

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Software Mentioned

SPSS
Statistical Package for the Social Sciences

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