A retrospective analysis of high sensitivity cardiac troponin-T ranges in non-myocardial infarction emergency department visits.

BMC Cardiovascular Disorders
Nathan KongCorey E Tabit

Abstract

Current evidence suggests that high sensitivity cardiac troponin-T (hs-cTnT) values differ based on sex, race, age, and kidney function. However, most studies examining the relationship of hs-cTnT and these individual factors are in healthy participants, leading to difficulty in interpreting hs-cTnT values in the Emergency Department (ED) setting. We seek to examine the relationship between hs-cTnT values and sex, race, age, and kidney function in a contemporary, urban academic setting. ED visits from June 2018 through April 2019 with at least 1 hs-cTnT and no diagnosis of acute myocardial infarction (AMI) at an academic medical center in the south side of Chicago were retrospectively analyzed. Median hs-cTnT values were stratified by sex (male or female), race (African American or Caucasian), age, estimated glomerular filtration rate (eGFR), and stage of chronic kidney disease. 9679 encounters, representing 7989 distinct patients, were included for analysis (age 58 ± 18 years, 59% female, 85% black). Males had significantly higher median hs-cTnT values than females (16 [8-34] vs. 9 [6-22] ng/L, p < 0.001), African Americans had a significantly lower median value than Caucasians (10 [6-24] vs. 15 [6-29] ng/L, p < 0.001), and th...Continue Reading

References

Dec 31, 2002·Journal of the American College of Cardiology·Benjamin J FredaGary S Francis
Jul 16, 2003·Annals of Internal Medicine·Andrew S LeveyUNKNOWN National Kidney Foundation
Dec 24, 2003·Circulation·Jart H C DirisMarja P van Dieijen-Visser
Aug 28, 2009·The New England Journal of Medicine·Tobias ReichlinChristian Mueller
Feb 18, 2014·Journal of the American College of Cardiology·M Odette GoreJames A de Lemos
Feb 17, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Dina N GreeneAlan S Go
Jan 16, 2016·Clinical Biochemistry·Tuncay GucluDogan Yucel
Sep 14, 2019·Journal of the American Heart Association·Eddie HacklerJames A de Lemos
Nov 10, 2020·The American Journal of Cardiology·Rabih R AzarEvangelos Giannitsis

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