A retrospective analysis of morphokinetic parameters according to the implantation outcome of IVF treatment

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Lihong WuGuo Ning Huang

Abstract

The aim of this study was to identify candidates for a morphokinetic embryo selection model for day-3 transfer through the analysis of known implantation data. A diagnostic trial study was conducted. Two hundred twelve embryos from 109 patients participating in in-vitro fertilization (IVF) protocols. In this diagnostic trial study, we analyzed cleavage times of transferred embryos with either failed (n=102) or full implantations (n=110). The logistic regression (LR) model of the relationship between the morphokinetic parameters and the implantation rate had a sensitivity of 79.61% and specificity of 47.56%. Results also showed that morphokinetic parameters such as tPNf (the time when pronuclei disappearanced), t2 (t2 for two cells), t4 (t4 for four cells) and t4-t3 were significantly different between embryos in the two groups (p<0.037). Implantation rates of embryos within the time interval of 21.27 h< t2 < 26.725 h were higher than those of embryos outside this period (60.83% vs. 40.21%, p=0.003). Fifty-seven patients with fully implanted embryos included five patients with pregnancy loss and 52 patients with live births. Embryos that met the time interval criteria for t2 and were also within the range of 11h<t5-t4<13 h had s...Continue Reading

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Citations

Oct 4, 2016·Journal of Assisted Reproduction and Genetics·Liron Bar-ElDalit Ben-Yosef
Mar 25, 2020·Human Reproduction Open·UNKNOWN ESHRE Working group on Time-lapse technologyGiovanni Coticchio

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