A retrospective analysis of neoadjuvant platinum-based chemotherapy versus up-front surgery in advanced ovarian cancer

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
H SteedB Rosen

Abstract

The objective of this study is to compare progression-free survival (PFS) and overall survival (OS) of ovarian cancer patients treated with neoadjuvant chemotherapy and surgery to primary surgery and postoperative chemotherapy. Retrospective analysis from 1998 to 2003 of 116 patients with ovarian cancer was performed. Fifty women diagnosed by positive cytology received three cycles of carboplatin and paclitaxel. Thirty-six patients subsequently underwent cytoreductive surgery and completed three further cycles postoperatively. The OS and PFS were compared in 66 women treated with primary surgery and postoperative chemotherapy. A statistically significant difference was observed for OS (P= 0.03, HR = 1.85, CI = 1.06-3.23) and PFS (P= 0.04, HR = 1.61, CI = 1.03-2.53) favoring the primary surgery group. Due to the small numbers, age, grade, stage, pleural effusions, and histologic cell type were controlled for separately in the bivariate analyses. Controlling for stage made the results weaker. A matched subgroup survival analysis was performed on patients who had surgery following neoadjuvant chemotherapy. After matching for stage and grade and controlling age and pleural effusions (N= 28 matched pairs), there was no statistical d...Continue Reading

References

Nov 1, 1992·Gynecologic Oncology·S M EisenkopH J Wang
Mar 1, 1991·Gynecologic Oncology·M E PotterH M Shingleton
Jun 1, 1990·Gynecologic Oncology·J T ChambersP E Schwartz
Apr 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J R RedmanT B Hakes
Nov 18, 1993·The New England Journal of Medicine·S A Cannistra
Apr 1, 1994·Gynecologic Oncology·P E SchwartzR Makuch
Jan 1, 1996·European Journal of Gynaecological Oncology·A OnnisL Castellan
Jan 16, 1999·Gynecologic Oncology·P E SchwartzR P Thiel
Jul 13, 2000·Seminars in Oncology·R F Ozols
Sep 14, 2000·Gynecologic Oncology·A L Covens
Nov 7, 2001·European Journal of Gynaecological Oncology·F RecchiaS Rea
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert E BristowF J Montz
Mar 22, 2002·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·F KayikçiogluG Tulunay
Apr 6, 2002·Journal of Cancer Research and Clinical Oncology·J HuoberD Wallwiener
Dec 6, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M Baekelandt
Dec 17, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K ShibataS Mizutani

❮ Previous
Next ❯

Citations

Feb 6, 2013·Nature Reviews. Clinical Oncology·Robert L ColemanThomas J Herzog
Jul 2, 2010·Gynecologic Oncology·O C FreedmanH Mackay
Feb 27, 2010·Journal of Surgical Oncology·Lori E WeinbergJean A Hurteau
Apr 4, 2006·Journal of Theoretical Biology·M KohandelA Oza
Mar 20, 2012·Journal of Enzyme Inhibition and Medicinal Chemistry·Maja RadisavljevićMarijana Petković
Dec 11, 2013·Gynecologic Oncology·Carsten Lindberg Fagö-OlsenClaus Hoegdall
Aug 17, 2012·The Cochrane Database of Systematic Reviews·Jo MorrisonTheresa A Lawrie
Apr 29, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Gregg Van de PutteEric de Jonge
Jan 28, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Okechukwu A Ibeanu, Robert E Bristow
Aug 3, 2011·Expert Review of Anticancer Therapy·Takashi Onda, Hiroyuki Yoshikawa
Jun 12, 2018·Indian Journal of Surgical Oncology·Amrutha RamachandranDehannathparambil K Vijaykumar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.