Abstract
In this retrospective study we analyzed the age-related mortality and the long-term survival of a total of 2021 subjects (male: n=1509; female: n=512) who underwent major pulmonary resections (lobectomy, pneumonectomy) in curative intention for primary non-small cell lung cancer (NSCLC). As controls, patients were divided into three groups of age: subjects >75 years of age (n=119), subjects 65-75 years of age (n=587) and subjects <65 years of age (n=1315). Overall mortality after lobectomy was 1.4% (21/1505 patients); age-related mortality was 0.9% (n=8/919) in subjects aged <65 years, 1.9% (n=9/486) in subjects aged 65-75 years, and 4.0% (n=4/100) in subjects aged >75 years. Overall mortality after pneumonectomy was 4.3% (22/516 patients); age-related mortality was 3.0% (n=12/396) in subjects aged <65 years, 7.9% (n=8/101) in subjects aged 65-75 years, 10.5% (n=2/19) in subjects aged >75 years. The overall 5-year survival rates were 52.5% (age: <65 years), 45.8% (age: 65-75 years), and 50% (age: >75 years). There was no significant difference in overall survival between age groups. However, an impaired performance status (ECOG status grades 1-3) had a significant negative impact on survival in subjects >65 years (p=0.017), and...Continue Reading
References
Dec 1, 1982·American Journal of Clinical Oncology·M M OkenP P Carbone
Jun 1, 1997·Chest·C F Mountain, C M Dresler
Sep 3, 1998·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·S PagniR B Ponn
Apr 12, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·W DyszkiewiczL Gasiorowski
Dec 13, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·T AokiT Hirono
Feb 24, 2001·Thorax·UNKNOWN British Thoracic Society, UNKNOWN Society of Cardiothoracic Surgeons of Great Britain and Ireland Working Party
Oct 18, 2001·The Annals of Thoracic Surgery·D FangD Zhang
Feb 21, 2002·The European Respiratory Journal·J P van MeerbeeckM L Vos de Wael
Jun 18, 2002·Chest·Marc LickerJean-Marie Tschopp
Dec 21, 2002·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Kazumichi YamamotoFrancisco París Romeu
Jan 16, 2003·Chest·Michael A BecklesUNKNOWN American College of Chest Physicians
Apr 16, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Tadashi AokiJun-ichi Hayashi
Jan 17, 2004·The Annals of Thoracic Surgery·Malcolm V BrockStephen C Yang
Sep 15, 2004·Chest·Jeffrey L PortNasser K Altorki
Aug 2, 2005·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Hidehito MatsuokaNoriaki Tsubota
Aug 3, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tomoyuki GoyaUNKNOWN Japanese Joint Committee of Lung Cancer Registry
Sep 16, 2005·Chest·Shigeki SawadaMotohiro Yamashita
Oct 21, 2005·Chest·Vita SullivanRosemary F Kelly
Jul 26, 2006·The Annals of Thoracic Surgery·Robert J Cerfolio, Ayesha S Bryant
Sep 26, 2006·The Annals of Thoracic Surgery·Alberto Dominguez-VenturaPeter C Pairolero
Feb 27, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Francesco LeoLorenzo Spaggiari
Citations
Dec 25, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Vikas DudejaWaddah B Al-Refaie
Nov 26, 2008·American Journal of Respiratory and Critical Care Medicine·Max KatesJuan P Wisnivesky
May 2, 2009·Annals of Surgical Oncology·Keith SigelJuan Wisnivesky
Aug 18, 2009·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·F LöheM K Angele
Feb 18, 2016·Journal of Cancer Research and Therapeutics·Guangliang QiangDeruo Liu
May 18, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hunbogi ThorsteinssonTomas Gudbjartsson
Sep 29, 2011·Archives of Gerontology and Geriatrics·Faruk Tas, Serkan Keskin
Oct 7, 2015·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Xizhao SuiYun Li
Jul 11, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tobias SchulteRoland Kurdow
Mar 28, 2009·The Annals of Thoracic Surgery·Mark K FergusonWickii T Vigneswaran
Oct 6, 2010·Journal of Clinical Nursing·Kwua-Yun WangShih-Chun Lee
Dec 2, 2009·Cancer·Cornelis J A HaasbeekSuresh Senan
Mar 1, 2013·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Hung-Chang LiuYu-Jen Chen
May 12, 2012·Asian Pacific Journal of Tropical Medicine·Jing ZhangLi-Guo Yin
Mar 24, 2010·Interactive Cardiovascular and Thoracic Surgery·Andrea ZuinFederico Rea
Jun 20, 2019·PloS One·José Carlos R AlcantudMarcelo F Jiménez
Apr 11, 2013·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·Michael PapiashvilliIsrael E Priel
May 12, 2012·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·Michael PapiashvilliIlan Bar
Mar 7, 2017·Turkish Journal of Medical Sciences·İlknur AytekinLevent Elbeyli
Sep 12, 2020·Clinical Lung Cancer·Michiel A IjsseldijkAbraham Lebenthal