A retrospective analysis of the outcome of patients who have received two prior chemotherapy regimens including platinum and docetaxel for recurrent non-small-cell lung cancer

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
E MassarelliR S Herbst

Abstract

With the availability of chemotherapy agents for first- and second-line treatment of advanced non-small-cell lung cancer (NSCLC), the patient population that requires subsequent chemotherapy is increasing. This retrospective analysis was performed to describe the clinical course after two standard or approved chemotherapy agents in patients with good overall performance status. Data were selected from patients with advanced NSCLC who had received third- or fourth-line chemotherapy after two prior chemotherapy regimens that included platinum and docetaxel given concurrently or sequentially. Prior regiments had failed due to discase progression within 90 days of chemotherapy, or unacceptable toxicity. Examination of over 700 patient records between January 1993 and January 2000 at one US and one European cancer centre revealed 43 patients that fulfilled the inclusion criteria. Response rates decreased with each line of treatment: first line, 20.9%; second line, 16.3%; third line, 2.3%; and fourth line, 0%. The disease control rate (response plus stable disease) also decreased dramatically from first- to fourth-line treatment, although it was higher for second-line treatment (74.4%) than for first-line treatment (62.8%). The media...Continue Reading

References

Sep 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K S AlbainR B Livingston
Nov 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S FujinoA Mori
Jan 11, 2002·The New England Journal of Medicine·Joan H SchillerUNKNOWN Eastern Cooperative Oncology Group
Jun 6, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Katherine ThorntonRichard Pazdur

❮ Previous
Next ❯

Citations

Jun 12, 2008·JAMA : the Journal of the American Medical Association·Sarah Elizabeth Harrington, Thomas J Smith
Dec 2, 2004·Nature Reviews. Cancer·Roy S HerbstJosé Baselga
Jul 15, 2005·The New England Journal of Medicine·Frances A ShepherdUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Jun 25, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J-C SoriaV Papadimitrakopoulou
Oct 28, 2008·Japanese Journal of Clinical Oncology·Jong-Mu SunJong Seok Lee
Aug 2, 2012·Journal of the National Cancer Institute·Yue-Yung HuCaprice C Greenberg
Sep 29, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Etienne Giroux LeprieurBernard Milleron
May 18, 2011·Forschende Komplementärmedizin = Research in Complementary Medicine·Seong Ha CheonWan Kyu Eo
Sep 10, 2011·Therapeutic Advances in Medical Oncology·B K EcclesM T Lwin
Feb 23, 2005·Journal of Translational Medicine·Michael A MorseH Kim Lyerly
Jul 16, 2010·BMC Research Notes·Marios E Froudarakis, Evangelos Briasoulis
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher G AzzoliUNKNOWN American Society of Clinical Oncology
Jul 3, 2013·Journal of Oncology Practice·M Jennifer ChengThomas J Smith
Feb 18, 2014·International Journal of Clinical Oncology·Seigo MiyoshiJitsuo Higaki
Nov 26, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·V Zietemann, T Duell
Feb 24, 2016·Journal of Pain and Symptom Management·Melissa M GarridoPaul K Maciejewski
Feb 18, 2016·Journal of Cancer Research and Therapeutics·Ali Murat TatliHakan Sat Bozcuk
Feb 19, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Stéfanie HabibAlexis B Cortot
Nov 26, 2008·Revue des maladies respiratoires·M Paesmans
May 26, 2012·Journal of Vascular and Interventional Radiology : JVIR·Hyun J BangAllen C Goodman
Jun 4, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Marie FlorescuUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Nov 4, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Nicolas GirardVirginie Westeel
Oct 26, 2011·The Journal of Supportive Oncology·Erin AlesiThomas J Smith
Aug 12, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Mario ScartozziStefano Cascinu
Feb 5, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Diego DongiovanniMarina Schena
May 17, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Giorgio V ScagliottiChristian Manegold
Sep 26, 2003·Seminars in Surgical Oncology·Frank B ZimmermannBranislav Jeremic
Apr 8, 2004·Journal of Clinical Pharmacy and Therapeutics·M Ranson, S Wardell
Jun 30, 2009·Drug Development Research·David E Gerber
Jan 11, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Thomas A HensingMark A Socinski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
V Zietemann, T Duell
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Nasser HannaPaul A Bunn
© 2021 Meta ULC. All rights reserved