Abstract
Lokivetmab neutralizes IL-31, a cytokine that plays an important role in the pathogenesis of atopic dermatitis (AD) in dogs. To review experience of one year of treatment with lokivetmab for the control of pruritus in dogs with allergic dermatitis. Eighty dogs diagnosed with AD, ten with concurrent adverse food reaction and AD and 45 with allergic dermatitis of undetermined cause. Three dogs were lost to follow- up. Retrospective analysis of medical records of dogs with allergic dermatitis treated with lokivetmab from November 2015 to October 2016. Treatment success for owner-assessed pruritus was empirically defined as ≥2 cm reduction in Visual Analog Scale (pVAS) from baseline. A ≥50% reduction in pVAS also was recorded. Pruritus improvement was achieved in 116 of 132 dogs (87.8%) following initial lokivetmab administration at 1.8 to 3.7 mg/kg (P < 0.001). A pVAS reduction of ≥50% was recorded in 104 dogs (77.0%). Dogs with severe/very severe pruritus prior to treatment and large/giant sized dogs, had 2.7 and 2.8 times higher odds of treatment success, respectively. There were no significant associations between treatment success and age of onset of clinical signs, disease chronicity, lokivetmab dosage or age at initial lokiv...Continue Reading
References
Jan 28, 2009·Veterinary Dermatology·J RybnícekP B Hill
Mar 27, 2009·Veterinary Dermatology·Christine Loewenstein, Ralf S Mueller
Oct 11, 2011·European Journal of Cell Biology·Christian CornelissenBernhard Lüscher
Jan 22, 2013·Veterinary Dermatology·Andrea J GonzalesRobert B McCall
Jul 9, 2013·Veterinary Dermatology·Sallie B CosgroveMichael R Stegemann
Dec 11, 2013·Veterinary Immunology and Immunopathology·Erin E McCandlessAndrea J Gonzales
Feb 6, 2014·Journal of Veterinary Pharmacology and Therapeutics·A J GonzalesM Mitton-Fry
Sep 15, 2017·Veterinary Dermatology·Hilde MoyaertMichael R Stegemann
Citations
Sep 18, 2020·Veterinary Dermatology·Ina HerrmannThierry Olivry
Oct 28, 2019·Veterinary Dermatology·Claude FavrotAna Rostaher
Nov 26, 2020·Journal of Clinical Medicine·Masutaka Furue
Feb 16, 2021·Research in Veterinary Science·Sayaka ShiomitsuDomenico Santoro
Mar 2, 2021·Frontiers in Medicine·Kenji Kabashima, Hiroyuki Irie
Apr 13, 2021·The Veterinary Journal·Ralf S Mueller, Katrin Hartmann
Apr 22, 2021·Drugs·Youkyung S RohShawn G Kwatra
Jun 4, 2021·Veterinary Research·Solène NiederlenderGrégory Karadjian
Jun 10, 2021·Veterinary Dermatology·Peter CanningDaniel O Morris
Jun 29, 2021·Veterinary Dermatology·Leen Van BrusselMichael R Stegemann
Aug 21, 2021·Veterinary Dermatology·Emmanuel Bensignor, Emilie Videmont
Nov 20, 2021·Veterinary Dermatology·Chie Tamamoto-Mochizuki, Thierry Olivry
Dec 21, 2021·Frontiers in Veterinary Science·Ju-Yong ParkJung-Hyun Kim
Jan 12, 2022·Veterinary Dermatology·Daria DentiMichela De Lucia