A Retrospective Belgian Multi-Center MRI Biomarker Study in Alzheimer's Disease (REMEMBER)

Journal of Alzheimer's Disease : JAD
Ellis NiemantsverdrietSebastiaan Engelborghs

Abstract

Magnetic resonance imaging (MRI) acquisition/processing techniques assess brain volumes to explore neurodegeneration in Alzheimer's disease (AD). We examined the clinical utility of MSmetrix and investigated if automated MRI volumes could discriminate between groups covering the AD continuum and could be used as a predictor for clinical progression. The Belgian Dementia Council initiated a retrospective, multi-center study and analyzed whole brain (WB), grey matter (GM), white matter (WM), cerebrospinal fluid (CSF), cortical GM (CGM) volumes, and WM hyperintensities (WMH) using MSmetrix in the AD continuum. Baseline (n = 887) and follow-up (FU, n = 95) T1-weighted brain MRIs and time-linked neuropsychological data were available. The cohort consisted of cognitively healthy controls (HC, n = 93), subjective cognitive decline (n = 102), mild cognitive impairment (MCI, n = 379), and AD dementia (n = 313). Baseline WB and GM volumes could accurately discriminate between clinical diagnostic groups and were significantly decreased with increasing cognitive impairment. MCI patients had a significantly larger change in WB, GM, and CGM volumes based on two MRIs (n = 95) compared to HC (FU>24months, p = 0.020). Linear regression models s...Continue Reading

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Citations

Feb 6, 2020·International Journal of Geriatric Psychiatry·Noa BregmanUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Dec 22, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Jonas HannestadSteven Braithwaite
Aug 3, 2021·Journal of Alzheimer's Disease : JAD·Mandy Melissa Jane WittensSebastiaan Engelborghs

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Software Mentioned

MSmetrix
cross
GraphPad Prism
SPSS Statistics
REMEMBER

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