A Retrospective Case-Control Study to Evaluate the Diagnostic Accuracy of Honeycomb Sign in Melioid Liver Abscess

The American Journal of Tropical Medicine and Hygiene
Hannah L KhiangteSridhar Gibikote

Abstract

Among pyogenic liver abscesses, melioid etiology is considered in endemic regions in the presence of known health or occupational risk factors. "Honeycomb sign," used to describe an abscess with multiple internal septations dividing the abscess cavity into multiple loculations of comparable sizes on imaging, is a sensitive sign for melioid liver abscess. This is a retrospective case-control study investigating incidence, sensitivity, and specificity of "honeycomb sign" in melioid liver abscess, in a cohort of patients with culture-proven melioidosis infection. Abscesses ≥ 2 cm were analyzed for the honeycomb sign. P value < 0.05 was taken as statistically significant. Interobserver agreement was calculated between two radiologists for the presence of the sign, sensitivity, and specificity. A total of 40 abscesses were analyzed. Thirty-four abscesses (85%) manifested the honeycomb sign with interobserver agreement (kappa = 0.70 and 0.92). Sensitivity of the sign is 85% (95% confidence interval [CI]: 70-94%), specificity is 75% (95% CI: 59-87%), positive predictive value is 77% (95% CI: 62-88%), and negative predictive value is 83% (95% CI: 67-94%). If abscess size is ≥ 3 cm, the sensitivity is 91% (95% CI: 77-98%), specificity i...Continue Reading

References

May 1, 1996·Annals of Surgery·C J HuangG D Zuidema
Jun 2, 2000·Radiographics : a Review Publication of the Radiological Society of North America, Inc·I PedrosaC S Pedrosa
Nov 6, 2001·The American Journal of Tropical Medicine and Hygiene·W J MunckhofB J Currie
Nov 28, 2002·QJM : Monthly Journal of the Association of Physicians·A H MohsenM W McKendrick
May 28, 2003·Lancet·N J White
Mar 3, 2005·Journal of Gastroenterology and Hepatology·Kirien T Kjossev, Julian E Losanoff
Apr 16, 2005·Clinical Microbiology Reviews·Allen C Cheng, Bart J Currie
Mar 3, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anucha ApisarnthanarakLinda M Mundy
Jun 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Vui Heng Chong
Jun 22, 2007·Indian Journal of Medical Microbiology·A MukhopadhyaG Kurian
Dec 23, 2008·The British Journal of Radiology·M MuttarakC Sivasomboon
Apr 20, 2011·Journal of Medical Imaging and Radiation Oncology·Piyaporn ApisarnthanarakAnucha Apisarnthanarak
Mar 13, 2014·International Journal of Antimicrobial Agents·David Dance
Jul 9, 2014·Journal of Tropical Medicine·Soumik GhoshNaveen Kumar
Oct 18, 2014·World Journal of Clinical Cases·Partha PalKokila Banerjee
Oct 27, 2015·Insights Into Imaging·Chandan KakkarAnkur Arora
Jun 25, 2016·AJR. American Journal of Roentgenology·Ali Devrim KaraosmanogluMusturay Karcaaltincaba
May 4, 2017·IDCases·Nobuaki Mori, Koichi Murakami
Jul 14, 2017·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Isabella PrincessM A Thirunarayan
Oct 11, 2017·The American Journal of Tropical Medicine and Hygiene·Alice YoungJosh Hanson

❮ Previous
Next ❯

Citations

Jun 3, 2020·The American Journal of Tropical Medicine and Hygiene·Michaëla A M HusonAndreas Neumayr
May 7, 2020·The American Journal of Tropical Medicine and Hygiene·Daniel Kaminstein
Mar 13, 2020·Clinical Microbiology Reviews·I GassiepR Norton
Jan 5, 2021·QJM : Monthly Journal of the Association of Physicians·M U MalikP L Chong
Nov 13, 2021·Zeitschrift für Gastroenterologie·Nitin ChaubalChristoph F Dietrich

❮ Previous
Next ❯

Related Concepts

Related Papers

The Surgical Clinics of North America
H S Goldsmith, W F Chen
European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
P FernandezD Ducassou
Klinichna khirurhiia
M G Shevchuk, L G Babenko
© 2022 Meta ULC. All rights reserved