Abstract
The single most important prognostic indicator for mortality in patients with cutaneous squamous cell carcinoma (SCC) is the development of nodal metastasis (NM). To characterize the risk factors for and clinical course of cutaneous SCC with NM. Ten-year retrospective cohort study (2006-2017) at an academic tertiary care center reviewing 53 cutaneous SCC tumors with NM. Most patients were men (84.6%, 44/52), and almost all primary tumors were on the head and neck (96.2%, 51/53). Most primary tumors were characterized by known "high-risk features" including perineural invasion (56.6%, 30/53), diameter ≥2 cm (54.7%, 29/53), invasion beyond subcutaneous fat (43.4%, 23/53), and poor differentiation (32.1%, 17/53). In addition, many tumors were recurrent (52.8%, 28/53), and many patients were immunosuppressed (30.8%, 16/52). Disease-free survival after treatment of nodal disease was 7.5% (4/53) at 5 years. To the best of the authors' knowledge, this study is the largest retrospective cohort of cutaneous SCC with NM to date. The results verify the significance of "high-risk features" used by current staging systems while highlighting additional features that may have prognostic value. This study may be used to refine current staging ...Continue Reading
References
Sep 1, 1992·The Australian and New Zealand Journal of Surgery·M G JosephP J Kennedy
May 1, 1994·Journal of the American Academy of Dermatology·D L Miller, M A Weinstock
Feb 1, 1996·The Laryngoscope·E Tavin, M Persky
May 30, 1998·Archives of Otolaryngology--head & Neck Surgery·D H KrausL B Harrison
May 1, 1999·Cancer·M J VenessG W Morgan
Sep 28, 1999·Oncogene·N SoufirN Basset-Seguin
Mar 29, 2001·The New England Journal of Medicine·M Alam, D Ratner
Dec 9, 2004·Seminars in Cutaneous Medicine and Surgery·Conway C Huang, Sarah M Boyce
Feb 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gary L ClaymanScott M Lippman
Sep 9, 2005·The Laryngoscope·Brian A MooreGary L Clayman
Jun 22, 2006·Annals of Surgical Oncology·John T MullenJanice N Cormier
Jun 2, 2007·Journal of Biomedicine & Biotechnology·Michael J Veness
Sep 6, 2007·Skinmed·Sara HermanDésirée Ratner
Jul 12, 2008·The Lancet Oncology·Kay D BrantschHelmut Breuninger
Aug 29, 2009·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Constantinos MourouzisClive Pratt
Mar 17, 2010·Archives of Dermatology·Howard W RogersBrett M Coldiron
Jun 15, 2010·Clinics in Dermatology·Ross M Levy, C William Hanke
May 18, 2012·Journal of Surgical Oncology·Nicholas D L S BroughamSwee T Tan
Jun 20, 2012·Archives of Dermatology·Jo Leonardi-BeeFiona Bath-Hextall
Jan 18, 2013·JAMA Dermatology·Anokhi Jambusaria-PahlajaniChrysalyne D Schmults
Feb 5, 2013·Journal of the American Academy of Dermatology·Pritesh S KariaChrysalyne D Schmults
May 17, 2013·JAMA Dermatology·Chrysalyne D SchmultsAbrar A Qureshi
Nov 15, 2013·JAMA Dermatology·Adam R SchmittChristian L Baum
Dec 25, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pritesh S KariaChrysalyne D Schmults
Sep 4, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·K WermkerC Hallermann
Jan 16, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yvonne Y LiPeter S Hammerman
Jul 30, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alexander StratigosUNKNOWN European Organization for Research and Treatment of Cancer (EORTC)
Jan 15, 2016·JAMA Dermatology·Agnieszka K ThompsonChristian L Baum
Apr 4, 2017·Head & Neck·Bruce G AshfordMarie Ranson
Aug 11, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Omeed AhadiatAshley Wysong
Oct 7, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Catherine ZilbergRuta Gupta
Dec 21, 2017·JAMA Dermatology·Pritesh S KariaChrysalyne D Schmults
Oct 26, 2018·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Christine DierickxStina Blomster
Citations
May 24, 2019·Clinical and Experimental Dermatology·Z Ali, P M Todd
May 1, 2020·Current Medical Research and Opinion·Aaron S FarbergScott M Dinehart
Nov 12, 2020·International Journal of Clinical Oncology·Yuki SaitoTatsuya Takenouchi
Apr 29, 2020·Journal of the American Academy of Dermatology·Ashley WysongSarah T Arron
Nov 10, 2020·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Marissa LoblAshley Wysong
Mar 19, 2021·Archives of Dermatological Research·Marissa B LoblAshley Wysong
Apr 3, 2021·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Mariam B TotonchySean R Christensen
Jun 8, 2021·Head & Neck·Jason G NewmanShlomo A Koyfman
May 15, 2021·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Valérie Tremblay-AbelÉmilie Perron
Nov 29, 2020·Seminars in Nuclear Medicine·Andrea SkanjetiFrancesco Giammarile
Dec 3, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·E de JongJ N Bouwes Bavinck
Jan 8, 2022·Dermatology and Therapy·Aaron S FarbergSarah T Arron