A retrospective cohort study of Southeast Asian patients with large congenital melanocytic nevi and the risk of melanoma development

Journal of the American Academy of Dermatology
Yuin-Chew Chan, Yoke-Chin Giam

Abstract

The lifetime risk of developing melanoma in Caucasian patients with large congenital melanocytic nevi (LCMN) is estimated to be between 4.5% and 10%. Cohort studies of LCMN and the risk of melanoma development in an Asian population are not available. We sought to determine the risk of melanoma development in a retrospective cohort of patients presenting with LCMN to a dermatology tertiary referral center in Singapore from January 1989 to December 2004. Patients with congenital melanocytic nevi (CMN) that covered at least 5% of the body surface area were included in the study. Data were obtained from electronic records and photographic documentation. A search for malignancy was done using the National Cancer Registry database. In all, 39 patients (23 male and 16 female) met the study criteria of LCMN; 15 of 39 patients also met the criteria of having a giant CMN (ie, a CMN that is predicted to be at least 20-cm diameter in adulthood). There were 29 Chinese, 6 Malay, 1 Indian, and 3 Caucasian patients. Their ages ranged from 23 months to 60 years (mean 18.8 years). They presented at a mean age of 26 months and were followed up for an average of 16.9 years. The size of the LCMN ranged from 5% to 40% of body surface area, with a m...Continue Reading

References

Apr 1, 1995·Journal of the American Academy of Dermatology·A J SwerdlowZ Qiao
Sep 1, 1996·Pediatric Dermatology·T KoyamaT Masuda
Dec 8, 1998·Journal of the American Academy of Dermatology·C L EganA C Halpern
Feb 13, 2001·Clinical and Experimental Dermatology·H M KootA P Oranje
Feb 24, 2001·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·J BohnM Aberg
Apr 14, 2004·Pediatric Dermatology·Ramón Ruiz-Maldonado
Nov 19, 2004·International Journal of Clinical Oncology·Partha Pratim MohantyNiloy Ranjan Datta
Apr 29, 2005·Journal of the American Academy of Dermatology·Bari Joan Bett
Apr 16, 2011·Dermatology : International Journal for Clinical and Investigative Dermatology·Y H HuangC C Hsieh

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Citations

Jan 12, 2011·Indian Journal of Dermatology, Venereology and Leprology·G Raghurama RaoUNKNOWN Sujatha
Apr 29, 2009·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Kazuo KishiTatsuo Nakajima
Oct 16, 2008·The Australasian Journal of Dermatology·Liang Joo Leow, Boon Kee Goh
Mar 8, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·N ZhangT W Gao
Nov 13, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·R Happle
Feb 11, 2021·Plastic and Reconstructive Surgery. Global Open·Kento TakayaKazuo Kishi

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