A retrospective comparison of pregnancy outcomes between women with alpha-thalassaemia 1 trait and normal controls

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
Kuntharee TraisrisilpTheera Tongsong

Abstract

The objective of this retrospective cohort study was to compare pregnancy outcomes between low-risk pregnant women with alpha-thalassaemia-1 trait and normal controls. The database of the Maternal-Foetal Medicine unit was used to identify low-risk singleton pregnant women complicated by alpha-thalassaemia-1 trait who gave birth between January 2002 and October 2014. The low-risk pregnancies with non-carrier status for thalassaemia were assigned into the control group, with a control-to-case ratio of 10:1. During the study period, 595 women with alpha-thalassaemia-1 trait and 5950 normal controls were identified. There was no significant difference in the incidence of preterm birth and most obstetric outcomes between the two groups. However, a statistically significant difference was detected between them in terms of gestational age at delivery, 37.76 ± 2.81 vs. 38.11 ± 2.50 weeks (p = .001), birth weight, 2876 ± 581 vs. 2948 ± 527 g (p = .002) as well as the rate of low-birth weight, 17.1 vs. 12.8% (p = .002). In conclusion, this study provides new insights that alpha-thalassaemia-1 trait has minimal effect on gestational age at delivery and low-birth weight whereas other common adverse pregnancy outcomes are not increased. Imp...Continue Reading

References

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Related Concepts

Gestational Age
Low Birth Weight Infant
Pregnancy Complications, Hematologic
Pregnancy Outcome
Retrospective Studies
Alpha-Thalassemia
Anemia
Birth
Physicians
Pregnant Women

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