A Retrospective Investigation of Clozapine Treatment in Autistic and Nonautistic Children and Adolescents in an Inpatient Clinic in Turkey

Journal of Child and Adolescent Psychopharmacology
Ozhan YalcinOzden Sukran Uneri

Abstract

The aim of this retrospective study is to examine the clinical outcomes and safety of clozapine in children and adolescents with schizophrenia or other psychotic disorders/autism spectrum disorder (ASD) or affective disorders. The inpatient and outpatient files of all children and adolescents treated with clozapine over a period of 34 months (from October 2011 to July 2014) were reviewed. Demographic and clinical data were examined to describe clinical and metabolic findings, dosing, and tolerability of clozapine treatment in youth with schizophrenia, other psychotic disorders, ASD, or bipolar disorder. The 37 pediatric patients included 26 patients with schizophrenia or other psychotic disorders, 7 patients with ASD complicated by schizophrenia or other psychotic disorders or affective disorders, and 4 patients with ASD only. In all groups (n = 37) there was a significant reduction (p < 0.001) in Brief Psychiatric Rating Scale (BPRS) points after clozapine treatment during the inpatient period (38.78 ± 27.75 days). In patients with schizophrenia or other psychotic disorders co-occurring with ASD or not (n = 31), there was a significant improvement in psychotic symptoms according to Positive and Negative Syndrome Scale (PANSS) ...Continue Reading

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Citations

Jun 14, 2017·Journal of Neuroscience Research·Roberto Cuevas-OlguinMarco Atzori
Oct 5, 2018·Journal of Clinical Psychopharmacology·Maud RothärmelOlivier Guillin
Oct 26, 2018·Journal of Child and Adolescent Psychopharmacology·Laura M SteinauerJennifer L Vande Voort
May 15, 2019·American Journal of Therapeutics·Vivekananda RachamalluManish Aligeti
Apr 16, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Antonio M PersicoCelso Arango
Jul 21, 2021·Journal of Child and Adolescent Psychopharmacology·Gul KaracetinYesim Saglam

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Methods Mentioned

BETA
sedation

Software Mentioned

SPSS
VEOS

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