A retrospective managed care claims data analysis of medication adherence to vaginal estrogen therapy: implications for clinical practice

Journal of Women's Health
Lee P ShulmanChris L Pashos

Abstract

This study sought to assess refill-based treatment duration and adherence to vaginal estrogen therapy (VET) in clinical practice and to compare treatment duration in women prescribed vaginal tablets (VT) or vaginal creams (VC) in clinical trials with that in clinical practice. Adults initiating VET between January and June 2004 were identified in 57 commercial health plans in the United States and followed for up to 10 months after treatment initiation. Treatment duration (Kaplan-Meier analysis) and adherence (medication possession ratio [MPR]) were examined for VC and VT cohorts and compared with a weighted average of treatment duration calculated for seven clinical trials identified in the literature. Of 13,074 women (mean age 54 +/- 9.1 years) identified, patients on VT had significantly longer treatment duration compared with patients on VC (149.1 +/- 101.1 days vs. 91.6 +/- 30.0 days, p < 0.01). Among 5,599 patients receiving multiple prescriptions, higher treatment durations were observed for both VT-treated and VC-treated patients (198.5 +/- 82.4 days vs. 177.1 +/- 86.7 days, p < 0.01) compared with 165 days observed in clinical trials. Medication adherence (MPR > or = 80%) was significantly higher among VT users compare...Continue Reading

References

Dec 1, 1995·Maturitas·G Bachmann
Oct 23, 1997·The American Journal of the Medical Sciences·L Pandit, J G Ouslander
May 26, 1998·JAMA : the Journal of the American Medical Association·J AvornJ LeLorier
Apr 4, 2000·Acta Obstetricia Et Gynecologica Scandinavica·R DugalE Wickstrøm
May 16, 2000·Menopause : the Journal of the North American Menopause Society·J E RiouxD S Hepburn
Sep 19, 2000·Menopause : the Journal of the North American Menopause Society·M Notelovitz, J H Mattox
Apr 20, 2001·Pharmacotherapy·L A Willhite, M B O'Connell
Jun 1, 2002·Obstetrics and Gynecology·M NotelovitzM Mazzeo
Aug 9, 2002·Journal of Affective Disorders·Jinmei LiGlen L Stimmel
Jan 27, 2005·Climacteric : the Journal of the International Menopause Society·N RaymundoN Calimon
Apr 5, 2005·Climacteric : the Journal of the International Menopause Society·E WeisbergI S Fraser

❮ Previous
Next ❯

Citations

Feb 17, 2010·Journal of Women's Health·Irwin Goldstein
Mar 13, 2014·Climacteric : the Journal of the International Menopause Society·S SalvatoreU Leone Roberti Maggiore
Nov 20, 2015·Climacteric : the Journal of the International Menopause Society·R E NappiM L Krychman
Feb 3, 2016·Climacteric : the Journal of the International Menopause Society·T TzurA Y Weintraub
May 27, 2010·The Journal of Sexual Medicine·Comfort Ibe, James A Simon
Nov 14, 2014·International Urogynecology Journal·David D RahnUNKNOWN Society of Gynecologic Surgeons Systematic Review Group
Feb 15, 2017·Menopause : the Journal of the North American Menopause Society·Sheryl A KingsbergGinger D Constantine
May 10, 2017·Menopause : the Journal of the North American Menopause Society·Amandeep S MahalEric R Sokol
Aug 8, 2018·Menopause : the Journal of the North American Menopause Society·Caroline M MitchellKatherine A Guthrie
Jul 16, 2009·Menopause : the Journal of the North American Menopause Society·David F Archer
Oct 2, 2019·Menopause : the Journal of the North American Menopause Society·Marie Fidela R ParaisoCheryl B Iglesia
Feb 9, 2017·Menopause : the Journal of the North American Menopause Society·Eric R Sokol, Mickey M Karram
Dec 7, 2017·Menopause : the Journal of the North American Menopause Society·Eric R Sokol
May 7, 2015·Menopause : the Journal of the North American Menopause Society·David PortmanNeeraj N Iyer
Nov 22, 2014·Obstetrics and Gynecology·David D RahnUNKNOWN Society of Gynecologic Surgeons Systematic Review Group
Sep 21, 2016·Menopause : the Journal of the North American Menopause Society·Alina Weissmann-BrennerIsrael Yoles
Jan 4, 2017·Climacteric : the Journal of the International Menopause Society·S PalaciosR Sanchez Borrego
Jan 18, 2018·Menopause : the Journal of the North American Menopause Society·Eric R Sokol
May 12, 2017·Therapeutic Advances in Medical Oncology·Mariana S SousaMichael Friedlander
Jul 13, 2016·Menopause : the Journal of the North American Menopause Society·Eric R Sokol, Mickey M Karram
Mar 13, 2021·Climacteric : the Journal of the International Menopause Society·S WeidlingerP Stute
Nov 24, 2021·Climacteric : the Journal of the International Menopause Society·S PalaciosM Lilue

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research
M AristidesNikos Maniadakis
Climacteric : the Journal of the International Menopause Society
Rossella E Nappi, Marta Kokot-Kierepa
© 2022 Meta ULC. All rights reserved