A Retrospective Review of Native Septic Arthritis in Patients: Can We Diagnose Based on Laboratory Values?

Curēus
Luke RasmussenBenjamin Wilke

Abstract

Introduction The accurate diagnosis of acute septic arthritis is essential to initiating appropriate treatment and minimizing potential cartilage damage. A synovial fluid cell count of 50,000 cells/mm3 has been used as a diagnostic cutoff for acute septic arthritis, although data supporting this is lacking. The purpose of this study was to assess the efficacy of synovial cell counts to predict septic arthritis in patients with symptomatic native joints. Methods A retrospective review was performed of patients who were evaluated for septic arthritis at a single institution with the use of synovial fluid analysis and adjunctive lab tests. Exclusion criteria included history of a total joint arthroplasty of the affected joint or immunocompromised state. A true infection was considered on the basis of positive or negative synovial aspirate cultures. We evaluated the synovial cell count, synovial polymorphonuclear cell percentile (% neutrophils), serum white blood cell (WBC), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) in order to determine their association and predictive power in a true infection. Results Of the 65 patients included in the study, 40 (61.5%) had a positive culture for septic arthritis and 25 ...Continue Reading

References

Jun 1, 1976·Annals of the Rheumatic Diseases·J H Newman
Dec 1, 1995·Arthritis and Rheumatism·C J KaandorpM A van de Laar
Dec 31, 1997·The American Journal of Emergency Medicine·G W JengC Y Chen
Jun 12, 1999·Annals of the Rheumatic Diseases·V C WestonM Doherty
Mar 15, 2003·Rheumatic Diseases Clinics of North America·Ignacio García-De La Torre
Jul 11, 2006·Rheumatology·G CoakleyUNKNOWN British Society for Rheumatology Standards, Guidelines and Audit Working Group
Jan 26, 2007·Emergency Medicine Journal : EMJ·S F LiJ Torres
Apr 5, 2007·JAMA : the Journal of the American Medical Association·Mary E MargarettenStephen Bent
Jun 6, 2008·Current Opinion in Rheumatology·Catherine J Mathews, Gerald Coakley
Oct 6, 2009·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Kenzo UchidaHisatoshi Baba
Mar 9, 2010·Lancet·Catherine J MathewsGerald Coakley
Aug 17, 2011·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Christopher R CarpenterJesse M Pines
Apr 18, 2013·Current Rheumatology Reports·Katie A SharffJohn M Townes
Aug 29, 2013·Clinical Orthopaedics and Related Research·Chika Edward Uzoigwe
Mar 19, 2019·Journal of Pediatric Orthopedics. Part B·Maki KinugasaRyosuke Kuroda

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