A retrospective review of whole bowel irrigation in pediatric patients

Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Jean C Y LoF Lee Cantrell

Abstract

Traditionally whole bowel irrigation (WBI) has been advocated for ingestions involving substances not bound with activated charcoal as well as extended release and enteric coated medications. Other than isolated case reports, little exists in the literature regarding the use of WBI in poisoned pediatric patients. The purpose of this study is to better understand the use of WBI in pediatric patients. A retrospective chart review of California Poison Control System electronic database for human poisoning cases between the years 2000 and 2010 was performed. A total of 176 cases were identified. The most common age of poisoned patients that received WBI was 2 years. There were more pediatric patients who received WBI between 2000 and 2005 then between 2006 and 2010. The top three substances in which WBI was used were calcium channel blockers, iron, and antidepressants. There were 72 cases involving sustained release and delayed release substances. The top five sustained release/delayed release substances were nifedipine, bupropion, verapamil, diltiazem, and felodipine. Adverse drug reactions were noted in 17 patients, vomiting in 16 patients and abdominal pain in one patient. In 36 cases, abdominal radiographs were performed. Sixte...Continue Reading

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Citations

Oct 7, 2014·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·M St-OngeR Blais
Dec 17, 2014·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Ruben ThanacoodyBruno Mégarbane
Oct 18, 2016·Critical Care Medicine·Maude St-OngeBruno Mégarbane
Feb 11, 2014·Pediatric Gastroenterology, Hepatology & Nutrition·Jae Hyug Woo, Eell Ryoo
Aug 29, 2018·BMJ Case Reports·Fiqry Fadhlillah, Shashank Patil
Jan 25, 2020·Clinical Pediatrics·James B LeonardWendy Klein-Schwartz
Feb 14, 2020·BMJ Case Reports·Gerd XuerebDavid Pace
Oct 24, 2020·Drug and Therapeutics Bulletin·Gerd XuerebDavid Pace

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