A retrospective study of 152 women with vaginal intraepithelial neoplasia

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Jing ZhangShulan Zhang

Abstract

To analyze the clinical characteristics and treatment of women with vaginal intraepithelial neoplasia (VAIN), as well as HPV prevalence in this population. A retrospective review was undertaken of the medical records of women diagnosed with VAIN at a clinic in Shenyang, China, between January 1, 2009, and December 31, 2012. Of the 152 records reviewed, 69 (45.4%) women had low-grade VAIN (VAIN1) and 83 (54.6%) had high-grade VAIN (VAIN2/3). Among 110 patients with an available HPV status, 97 (88.2%) were positive. The predominant HPV types were HPV16, HPV33, HPV81, HPV53, HPV18, HPV58, and HPV66. Previous hysterectomy was documented in 60 (39.5%) patients. Additionally, 80 (52.6%) patients had no history of dysplasia of the lower genital tract. Of patients with VAIN1, 50 (72.5%) were treated by observation only, 31 (62.0%) of whom regressed spontaneously. Of 66 patients with VAIN2, 38 (57.6%) underwent treatment, 14 (36.8%) of whom experienced recurrence or progression. Of 17 patients with VAIN3, 13 (76.5%) underwent treatment, 5 (38.5%) of whom experienced recurrence or progression. Evaluation of the entire vagina by colposcopy is warranted in each patient with abnormal cervical screening results. The predominant HPV genotypes...Continue Reading

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Citations

Dec 19, 2018·International Journal of Cancer. Journal International Du Cancer·Hanna Kristina BertoliSusanne K Kjaer
Dec 21, 2019·Journal of Lower Genital Tract Disease·Alexander FieldKhalil Razvi
Oct 24, 2019·Journal of Medical Virology·Shitai ZhangToshiyuki Sasagawa
Dec 30, 2016·Advanced Materials·Lindsey HinesMetin Sitti
Jul 1, 2020·International Journal of Clinical Practice·Argirios RountisDimitrios Haidopoulos
Nov 7, 2019·Journal of Obstetrics and Gynaecology of India·Priya BhatiAbraham Peedicayil

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