A retrospective study of clinical characteristics of interstitial lung disease associated with rheumatoid arthritis in Chinese patients

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Jun-Xiang Wang, Chuan-Guo Du

Abstract

Interstitial lung disease (ILD) in rheumatoid arthritis (RA) is associated with a poor prognosis. The purpose of this study was to assess the characteristics of ILD that are associated with RA. This was a retrospective study of 544 Chinese patients with RA (427 women and 117 men). RA-ILD was diagnosed by high-resolution computed tomography (HRCT). Patients with RA-ILD or with RA alone were compared in terms of age, sex distribution, duration of disease, clinical and laboratory parameters, history of smoking, and medication. Based on HRCT imaging, 83 (15.26%) patients with RA were diagnosed with ILD. ILD was more frequent in older patients (59.60±9.66 vs. 50.54±13.76 years, P<0.001), in those with a longer duration of disease (7.46±7.40 vs. 5.27±6.32 years, P=0.013) and in male patients (34.9% vs. 19.1%, P=0.001). RA-ILD was found to be associated with hepatitis B surface antigen (HBsAg) positivity (odds ratio [OR]=2.56, 95% confidence interval [95% CI] 1.02-6.43) and smoking (OR=3.38, 95% CI 1.65-6.95). Higher levels of C-reactive protein (OR=3.59, 95% CI 1.58-8.15), anti-cyclic citrullinated peptide (CCP) (OR=2.24, 95% CI 2.09-4.13), and rheumatoid factor (OR=3.72, 95% CI 1.56-8.86) were detected in association with RA-ILD. RA...Continue Reading

References

Feb 1, 1993·Baillière's Clinical Rheumatology·C A Kelly
Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine·E GabbayF R Lake
Feb 24, 2001·The New England Journal of Medicine·L M NogeeJ A Whitsett
May 15, 2002·Annals of the Rheumatic Diseases·J K DawsonD R Graham
Feb 18, 2004·Lancet·Justin McCurry
Aug 28, 2004·Clinics in Chest Medicine·Philippe CamusPascal Foucher
May 3, 2005·The European Respiratory Journal·J C Grutters, R M du Bois
Sep 1, 2005·Rheumatology International·Ayhan BilgiciM Danaci
Feb 21, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·P H CanterE Ernst
Jun 2, 2006·Arthritis and Rheumatism·Jasvinder A SinghUNKNOWN Classification and Response Criteria Subcommittee of the Committee on Quality Measures, American College of Rheumatology
Aug 24, 2006·Current Opinion in Pulmonary Medicine·Dong Soon Kim
Jul 28, 2007·Scandinavian Journal of Rheumatology·F WolfeK Michaud
Jan 30, 2008·Archives of Internal Medicine·Bernadette R GochuicoIvan O Rosas
Mar 13, 2010·Rheumatology·Gouri KoduriUNKNOWN ERAS (Early Rheumatoid Arthritis Study)
May 25, 2010·European Journal of Internal Medicine·J SchreiberR Merget
May 27, 2010·Clinical Rheumatology·Hisham M HabibMohamed A Marie
Jul 16, 2010·Current Rheumatology Reports·Dana P Ascherman
Dec 22, 2011·Experimental Lung Research·Rebecca C KeithDavid W H Riches
Mar 1, 2012·Clinics in Chest Medicine·Jürgen Behr
Sep 25, 2012·Seminars in Respiratory and Critical Care Medicine·Robert Vassallo
Aug 29, 2013·Clinical & Developmental Immunology·Juan ChenDana Ascherman
Feb 1, 2014·Seminars in Respiratory and Critical Care Medicine·Simon L F Walsh, David M Hansell

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Citations

Jan 25, 2017·Expert Opinion on Biological Therapy·Juan ChenXiaoming Liu
Jan 2, 2021·Seminars in Arthritis and Rheumatism·Janet E Pope, Ernest H Choy
Dec 22, 2020·Autoimmunity Reviews·Alessandro ConfortiPaola Cipriani
Nov 17, 2020·The Journal of Rheumatology·Vanessa L KronzerJeffrey A Sparks
Apr 13, 2020·Revue des maladies respiratoires·L SeséH Nunes

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