A retrospective study of increased plasma progestagen concentrations in compromised neonatal foals

Reproduction, Fertility, and Development
P RossdaleE Houghton

Abstract

Plasma progestagen concentrations were measured daily by radioimmunoassay (RIA) in 35 sick foals for the duration of their illness. The foals were divided into three groups on the basis of time to stand after birth. Foals were given intensive care treatment according to the severity of their illness. Plasma and urine concentrations of pregnenolone (P5) and pregnenediol (P5 beta beta) were measured by gas chromatography--mass spectrometry; plasma cortisol concentrations were measured by RIA and the foals' renal and respiratory status were assessed by creatinine clearance ratios and arterial oxygen concentrations respectively. Five patterns of plasma progestagen concentrations were identified; in general, values increased when the foal's clinical condition deteriorated and decreased as the foal improved. Median progestagen concentrations decreased over the first three days post partum in Group 1 foals but remained elevated in foals from Groups 2 and 3. Similar changes were observed in plasma P5 and P5 beta beta concentrations. Plasma cortisol concentrations were highest in foals from Groups 2 and 3 (P < 0.01) compared with foals from Group 1. Regardless of foal group, mean cortisol concentrations were highest (P < 0.001) in those...Continue Reading

Citations

Nov 30, 2006·The Veterinary Clinics of North America. Equine Practice·J C Ousey
Nov 28, 2015·The Veterinary Clinics of North America. Equine Practice·Brett S Tennent-BrownStephen Reed
Jan 15, 2015·Journal of Veterinary Emergency and Critical Care·Bettina Dunkel, Imogen C Johns
Jul 29, 2016·The Journal of Endocrinology·C J CorbinA J Conley
Feb 12, 1998·Journal of Veterinary Internal Medicine·V Buechner-MaxwellA Kristensen
Jun 1, 1997·Equine Veterinary Journal. Supplement·P ChavatteP D Rossdale
Dec 6, 2020·Journal of Veterinary Internal Medicine·Jacob M SwinkRamiro E Toribio

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