A retrospective study of the impact of 21-gene recurrence score assay on treatment choice in node positive micrometastatic breast cancer

Pharmaceuticals
Thomas G FrazierMichael S Broder

Abstract

To assess clinical utility of the 21-gene assay (Oncotype DX® Recurrence Score®), we determined whether women with HER2(-)/ER+ pN1mi breast cancer with low (<18) Recurrence Scores results are given adjuvant chemotherapy in a lower proportion than those with high scores (≥31). This was a multicenter chart review of ≥18 year old women with pN1mi breast cancer, HER2(-)/ER+ tumors, ductal/lobular/mixed histology, with the assay ordered on or after 1 January 2007. One hundred and eighty one patients had a mean age of 60.7 years; 82.9% had ECOG performance status 0; 33.7% had hypertension, 22.7% had osteoporosis, 18.8% had osteoarthritis, and 8.8% had type-2 diabetes. Mean Recurrence Score was 17.8 (range: 0-50). 48.6% had a mastectomy; 55.8% had a lumpectomy. 19.8% of low-risk group patients were recommended chemotherapy vs. 57.9% in the intermediate-risk group and 100% in the high-risk group (p < 0.001). A total of 80.2% of the low-risk group were recommended endocrine therapy alone, while 77.8% of the high-risk group were recommended both endocrine and chemotherapy (p < 0.001). The Oncotype DX Recurrence Score result provides actionable information that can be incorporated into treatment planning for women with HER2(-)/ER+ pN1mi b...Continue Reading

References

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Citations

Mar 28, 2019·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Wei-Rong ChenSan-Gang Wu
Jul 1, 2018·World Journal of Surgery·Hyeon Woo BaeByeong-Woo Park
Jun 27, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·R L N GodoneD B G Martins

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Methods Mentioned

BETA
biopsy
dissection
biopsies

Clinical Trials Mentioned

NCT00310180
NCT01272037

Software Mentioned

SAS

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