A retrospective study of the impact of lifestyle on age at onset of Huntington disease

Movement Disorders : Official Journal of the Movement Disorder Society
M Kaye TrembathMartin B Delatycki

Abstract

In transgenic mouse models of Huntington disease (HD) environmental enrichment significantly delays disease onset. A questionnaire-based survey of 154 adults with diagnosed HD (mean 4.2 years postdiagnosis) and a known IT15 CAG repeat length, explored whether premorbid lifestyle may relate to age-at-onset (AO). Participants were drawn from HD outpatient clinics in Australia and New Zealand. Premorbid physical, intellectual, and passive activity levels were used to generate scores in the categories of leisure, nonleisure (education, occupation and domestic duties) and total lifestyle. AO was associated with increased CAG repeat length as expected (r = -0.72, P < 0.001), but also with a lifestyle that included higher levels of passive activity (r = -0.38, P < 0.001). Multiple linear regression modeling showed lifestyle passivity to be a variable independent of CAG repeat length in predicting AO (R(2) = 0.54, b = -0.22, P = 0.005). Comparison of the mean AO across tertiles of lifestyle passivity scores showed onset 4.6 years (95% CI = 1.3-7.9) later in the least compared with the most passive tertile. CAG repeat length was also shown to predict lifestyle passivity (R(2) = 0.12, b = 1.08, P < 0.0005). Neither intellectual nor physi...Continue Reading

References

Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·D C RubinszteinD Craufurd
Apr 28, 2000·Nature·A van DellenA J Hannan
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·R P FriedlandS M Debanne
Mar 17, 2001·Nature Reviews. Neuroscience·J F Gusella, M E MacDonald
Nov 24, 2001·Brain Research Bulletin·F SquitieriM R Hayden
Feb 9, 2002·Annals of Neurology·Emma HocklyGillian P Bates
Feb 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wenzhen DuanMark P Mattson
Jun 5, 2003·American Journal of Medical Genetics. Part a·L DjousséR H Myers
Mar 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nancy S WexlerUNKNOWN U.S.-Venezuela Collaborative Research Project
Mar 18, 2004·Clinical Genetics·D R LangbehnUNKNOWN International Huntington's Disease Collaborative Group
May 26, 2004·Lancet Neurology·Laura FratiglioniBengt Winblad
Feb 25, 2005·Neurology·H ChenA Ascherio
Jun 14, 2006·Archives of Neurology·Jane S PaulsenUNKNOWN Predict-HD Investigators of the Huntington Study Group
Aug 19, 2006·Alzheimer Disease and Associated Disorders·Margaret GatzNancy L Pedersen
Aug 28, 2007·International Journal of Geriatric Psychiatry·Suvi RovioMiia Kivipelto
Mar 11, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Larissa ArningJörg T Epplen
Mar 3, 2009·Clinical Genetics·A NørremølleL Hasholt

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Citations

Aug 21, 2013·Trends in Molecular Medicine·Marguerite V Evans-GaleaRichard Saffery
May 17, 2014·Neurodegenerative Disease Management·Isabella Maria Sophie Mayer, Michael Orth
Aug 5, 2014·Neurobiology of Disease·Christina MoAnthony J Hannan
Feb 7, 2013·Molecular and Cellular Neurosciences·Mark I Ransome, Anthony J Hannan
Apr 24, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Marina PapoutsiJulie C Stout
May 16, 2014·Neurobiology of Disease·Christina MoAnthony J Hannan
Nov 30, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jess Nithianantharajah, Anthony J Hannan
Aug 7, 2013·Behavioural Brain Research·Christina MoAnthony J Hannan
Jan 24, 2017·Neurotoxicology·Ting-Kuang ChaoTamara Pringsheim
Oct 7, 2017·Journal of Huntington's Disease·Gabe KringlenDanny Bega
Sep 20, 2019·Genes·Carlo Maria Di LiegroItalia Di Liegro
May 11, 2020·Statistics in Medicine·Layla Parast, Beth Ann Griffin
Jan 23, 2021·Physical Therapy·Alvaro ReyesTravis M Cruickshank
May 14, 2021·Movement Disorders Clinical Practice·Kristina K CainMatthew J Barrett
Jun 12, 2020·Neurobiology of Disease·Carolina GubertAnthony J Hannan

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