PMID: 9433404Jan 1, 1997Paper

A retrospective study of treating RA patients with various combinations of slow-acting antirheumatic drugs in a county hospital

Scandinavian Journal of Rheumatology
T SokkaP Hannonen

Abstract

During the period 1/1990-9/1995 a total of 311 RA patients were challenged 458 times with 52 different COMBOs. As the first COMBO methotrexate (MTX), sulphasalazine (SSZ), im gold (GOLD), and hydroxychoroquine (HCQ) were combined with each other in 272/311 cases. The respective six and 12 months survivals of these COMBOs were 68.6% (95% CI 63.0% to 74.3%) and 53.6% (95% CI 47.4% to 59.9%). Inefficacy (27.9%), rather than adverse events (23.5%) or other causes (16.9%) was the leading reason for the discontinuations. Only in five cases (1.8%) these COMBOs were discontinued due to a remission. Not a single adverse event related to a COMBO treatment was judged as serious. The mean survival time for COMBOs including MTX (24.0 months; 95% CI 20.6 to 27.4) was statistically significantly longer than the respective time for COMBOs without MTX (14.5 months; 95% CI 11.2 to 17.7). We conclude that, when meticulously monitored, the treatment with COMBOs is safe. However, their efficacy on patients with advanced RA is modest. The survival time for COMBOs including MTX is longer than COMBOs without MTX.

References

Feb 1, 1987·British Journal of Rheumatology·A J TaggartV Wright
Aug 1, 1987·British Journal of Rheumatology·T GibsonG S Panayi
Oct 8, 1982·JAMA : the Journal of the American Medical Association·D J McCarty, G F Carrera
Oct 1, 1981·Arthritis and Rheumatism·R S PinalsR A Larsen
Oct 1, 1993·Seminars in Arthritis and Rheumatism·H E Paulus
Dec 1, 1995·Annals of the Rheumatic Diseases·H R Barthel, G R Burmester
Nov 1, 1995·Baillière's Clinical Rheumatology·F Wolfe
Jun 1, 1996·Arthritis and Rheumatism·T MöttönenM Leirisalo-Repo

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Citations

Apr 26, 2008·Modern Rheumatology·Tuulikki SokkaTheodore Pincus
Nov 17, 2005·Rheumatic Diseases Clinics of North America·Tuulikki SokkaTimo Möttönen
May 19, 2001·Best Practice & Research. Clinical Rheumatology·T Pincus, T Sokka

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