A retrospective study on the incidences of adverse drug events and analysis of the contributing trigger factors

Journal of Basic and Clinical Pharmacy
Aaseer Thamby SamSubramani Parasuraman

Abstract

To retrospectively determine the extent and types of adverse drug events (ADEs) from the patient cases sheets and identify the contributing factors of medication errors. To assess causality and severity using the World Health Organization (WHO) probability scale and Hartwig's scale, respectively. Hundred patient case sheets were randomly selected, modified version of the Institute for Healthcare Improvement (IHI) Global Trigger Tool was utilized to identify the ADEs; causality and severity were calculated utilizing the WHO probability scale and Hartwig's severity assessment scale, respectively. In total, 153 adverse events (AEs) were identified using the IHI Global Trigger Tool. Majority of the AEs are due to medication errors (46.41%) followed by 60 adverse drug reactions (ADRs), 15 therapeutic failure incidents, and 7 over-dose cases. Out of the 153 AEs, 60 are due to ADRs such as rashes, nausea, and vomiting. Therapeutic failure contributes 9.80% of the AEs, while overdose contributes to 4.58% of the total 153 AEs. Using the trigger tools, we were able to detect 45 positive triggers in 36 patient records. Among it, 19 AEs were identified in 15 patient records. The percentage of AE/100 patients is 17%. The average ADEs/1000 d...Continue Reading

References

Nov 1, 1981·Journal of the American Geriatrics Society·L E KleinD M Levine
Jun 28, 2011·Journal of Pharmacology & Pharmacotherapeutics·Harminder SinghNavin Dulhani
Oct 26, 2011·Journal of Pharmacology & Pharmacotherapeutics·R PriyadharsiniFiroj Kumar Sahoo
Jan 10, 2012·Journal of Young Pharmacists : JYP·Uv MatetiP Ramachandran
Apr 27, 2012·North American Journal of Medical Sciences·Uday Venkat MatetiPadmakumar Ramachandran

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Citations

Jul 27, 2015·Annals of Emergency Medicine·Michael Gottlieb, John Bailitz
Jun 7, 2018·British Journal of Clinical Pharmacology·Maria das Dores Graciano SilvaAntonio Luiz Pinho Ribeiro

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Software Mentioned

IHI Global Trigger Tool
Statistical Package for the Social Sciences ( SPSS )
Trigger
IHI

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