A retrospective study on the therapeutic effects of sodium bicarbonate for adult in-hospital cardiac arrest.

Scientific Reports
Chih-Hung WangWen-Jone Chen

Abstract

To investigate whether the effects of sodium bicarbonate (SB) during cardiopulmonary resuscitation (CPR) would be influenced by blood pH and administration timing. Adult patients experiencing in-hospital cardiac arrest (IHCA) from 2006 to 2015 were retrospectively screened. Early intra-arrest blood gas data were obtained within 10 min of CPR. Multivariable logistic regression analysis and generalised additive models were used for effect estimation and data exploration, respectively. A total of 1060 patients were included. Only 59 patients demonstrated favourable neurological status at hospital discharge. Blood pH ≤ 7.18 was inversely associated with favourable neurological outcome (odds ratio [OR], 0.24; 95% confidence interval [CI], 0.11-0.52; p value < 0.001) while SB use was not. In the interaction analysis for favourable neurological outcome, significant interactions were noted between SB use and time to SB (SB use × time to SB ≥ 20 min; OR 6.16; 95% CI 1.42-26.75; p value = 0.02). In the interaction analysis for survival to hospital discharge, significant interactions were noted between SB use and blood pH (Non-SB use × blood pH > 7.18; OR 1.56; 95% CI 1.01-2.41; p value = 0.05). SB should not be empirically administered f...Continue Reading

References

Jan 1, 1992·The American Journal of Emergency Medicine·T P AufderheideB Thompson
Jul 10, 2002·Resuscitation·Gad Bar-JosephUNKNOWN Brain Resuscitation Clinical Trial III (BRCT III) Study Group
Dec 17, 2002·JAMA : the Journal of the American Medical Association·Myron L Weisfeldt, Lance B Becker
Feb 24, 2006·The American Journal of Emergency Medicine·Rade B VukmirUNKNOWN Sodium Bicarbonate Study Group
Jul 2, 2009·The Annals of Pharmacotherapy·Matthew J GeraciJason Persoff
Mar 24, 2010·Nature Reviews. Nephrology·Jeffrey A Kraut, Nicolaos E Madias
Oct 5, 2011·Circulation·Lance B BeckerUNKNOWN Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation
May 30, 2012·Archives of Internal Medicine·Paul S ChanUNKNOWN Get With the Guidelines-Resuscitation Registry Investigators
Jan 24, 2015·Resuscitation·Tia T RaymondUNKNOWN American Heart Association's Get With The Guidelines-Resuscitation Investigators
Oct 20, 2015·Resuscitation·Jasmeet SoarUNKNOWN Adult advanced life support section Collaborators
Mar 18, 2016·Journal of Clinical Medicine Research·Dimitrios VelissarisMenelaos Karanikolas
Jan 27, 2017·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Feb 18, 1974·JAMA : the Journal of the American Medical Association
Dec 23, 2017·Critical Care : the Official Journal of the Critical Care Forum·Jonghwan ShinSeong Youn Hwang
Feb 10, 2018·Resuscitation·Lars W AndersenMichael W Donnino
Apr 14, 2018·The American Journal of Emergency Medicine·Chi-Chun LinCheng-Yu Chien
Nov 9, 2018·Critical Care Medicine·Ari MoskowitzUNKNOWN American Heart Association’s Get With The Guidelines – Resuscitation Investigators
Sep 9, 2019·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chih-Hung WangWen-Jone Chen

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R
R Foundation for Statistical Computing

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