A retrospective study to identify risk factors for somnolence and dizziness in patients treated with pregabalin

Journal of Pharmaceutical Health Care and Sciences
Hiroshi KatoKiyofumi Yamada

Abstract

Pregabalin is a therapeutic drug for neuropathic pain that is associated with somnolence and dizziness. These adverse events are often experienced shortly after initiating pregabalin, and may lead to treatment discontinuation. The purpose of this study was to explore factors that influence the incidence of somnolence and dizziness induced by pregabalin, and to identify patients at higher risk of adverse events. A retrospective analysis was conducted of patient characteristics (age, gender, renal function, initial daily dose of pregabalin, co-administration of strong opioids and hypnotics) and the incidence of somnolence and dizziness during the first week of pregabalin treatment. An electronic chart was used to collect data from 204 inpatients prescribed pregabalin at Nagoya University Hospital from June 2011 to November 2012. Among 36 patients who regularly received strong opioids, 18 (50.0 %) reported somnolence or dizziness during the first week of pregabalin treatment. The remaining 168 patients did not regularly receive strong opioids, and 25 (14.9 %) had an adverse event. In multivariate analysis, age (≧65 years, adjusted odds ratio: 2.507, 95 % CI: 1.164-5.397, p = 0.019) and regular co-administration of strong opioids (...Continue Reading

References

Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene
Jun 27, 2000·Anesthesia and Analgesia·K EckhardtG Mikus
Mar 18, 2003·Journal of Clinical Pharmacology·Edward J RandinitisHoward N Bockbrader
Aug 19, 2004·Epilepsia·Martin J Brodie
Jul 7, 2005·Neurology·Gordon A Irving
Jan 16, 2007·Trends in Pharmacological Sciences·David J DooleyDouglas Feltner
Jun 6, 2008·The Journal of Pain : Official Journal of the American Pain Society·Lesley M ArnoldGeorge Haig
Sep 9, 2008·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Petr VondracekPetr Gal
Oct 28, 2008·Seizure : the Journal of the British Epilepsy Association·Antonio Gil-NagelTeresa Leon
Aug 9, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kejia CaiC Neill Epperson
Mar 8, 2013·Pain Practice : the Official Journal of World Institute of Pain·Efklidis RaptisIoanna Siafaka
Aug 7, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Michael I BennettMeryem Nimour
Nov 28, 2013·Pain Practice : the Official Journal of World Institute of Pain·Rainer FreynhagenMark Latymer

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Citations

Feb 20, 2016·Journal of Pharmaceutical Health Care and Sciences·Hiroshi KatoKiyofumi Yamada
Nov 9, 2016·Journal of Pharmaceutical Health Care and Sciences·Ryo YajimaShiro Katayama
Dec 28, 2018·The Canadian Journal of Nursing Research = Revue Canadienne De Recherche En Sciences Infirmières·Sarah BenbowCatherine Ward-Griffin
Jul 6, 2018·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Mikito HirakataKoji Kawakami

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